التفاصيل البيبلوغرافية
| العنوان: |
Effect of CD8+ Cell Content on Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies. |
| المؤلفون: |
Moscardó, Federico1 moscardo_fed@gva.es, Sanz, Jaime1, Carbonell, Francisco2, Sanz, Miguel A.1, Larrea, Luis2, Montesinos, Pau1, Lorenzo, Ignacio1, Vera, Belén1, Boluda, Blanca1, Salazar, Claudia1, Cañigral, Carolina1, Planelles, Dolores2, Jarque, Isidro1, Solves, Pilar1, Martín, Guillermo1, López, Francisca1, de la Rubia, Javier1, Martínez, Jesús1, Carpio, Nelly1, Martínez-Cuadrón, David1 |
| المصدر: |
Biology of Blood & Marrow Transplantation. Nov2014, Vol. 20 Issue 11, p1744-1750. 7p. |
| مصطلحات موضوعية: |
*CD8 antigen, *NUCLEATION, *HEMATOLOGIC malignancies, *UMBILICAL cord, *CORD blood, *HLA histocompatibility antigens |
| مستخلص: |
Total nucleated (TNCs) and CD34 + cells are considered major determinants of outcome after umbilical cord blood (UCB) transplantation but the effect of other cell subtypes present in the graft is unknown. This single-center cohort study included patients with hematological malignancies who received UCB transplantation after a myeloablative conditioning regimen. UCB units were primarily selected according to cell content, both TNCs and CD34 + cells, and also according to the degree of HLA matching. Counts of several cell subtypes of the infused UCB unit, together with HLA disparities and other patient- and transplantation-related characteristics, were analyzed by multivariable methodology for their association with myeloid and platelet engraftment, graft-versus-host disease, nonrelapse mortality (NRM), disease-free survival (DFS), and overall survival (OS). Two hundred patients (median age, 32 years) were included in the study. In multivariable analyses, a greater number of CD8 + cells was significantly associated with better results for myeloid ( P = .001) and platelet ( P = .008) engraftment, NRM ( P = .02), DFS ( P = .007), and OS ( P = .01). CD34 + cell content was predictive of myeloid engraftment ( P < .001). This study suggests that the outcome after UCB transplantation in adults with hematological malignancies could be better when UCB grafts had a greater CD8 + cell content. [ABSTRACT FROM AUTHOR] |
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