التفاصيل البيبلوغرافية
| العنوان: |
Oxidative stress-mediated genotoxicity of malathion in human lymphocytes. |
| المؤلفون: |
Olakkaran, Shilpa1 (AUTHOR), Kizhakke Purayil, Anupama1 (AUTHOR), Antony, Anet1 (AUTHOR), Mallikarjunaiah, Shanthala2 (AUTHOR), Hunasanahally Puttaswamygowda, Gurushankara1 (AUTHOR) hpgurushankara@gmail.com |
| المصدر: |
Mutation Research - Genetic Toxicology & Environmental Mutagenesis. Jan2020, Vol. 849, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*MALATHION, *GENETIC toxicology, *ORGANOPHOSPHORUS pesticides, *LYMPHOCYTES, *FREE radicals, *GEL electrophoresis, *DNA damage |
| مستخلص: |
• Malathion is cytotoxic and genotoxic to human lymphocytes. • Malathion induces oxidative stress in human lymphocytes. • Malathion cause oxidative DNA damage. • Oxidative free radicals generated by malathion damage the pyrimidine bases. • Ethyl methane sulfonate generated oxidative free radicals damage the purine bases. Applying the single-cell gel electrophoresis (comet) assay, we show that the widely used organophosphorus pesticide malathion is cytotoxic, genotoxic, and induces oxidative stress in human lymphocytes. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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