Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms
| العنوان: | Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms |
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| المؤلفون: | Priska Stahel, Gary F. Lewis, Changting Xiao |
| المصدر: | Cellular and Molecular Gastroenterology and Hepatology Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 487-501 (2019) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, SMC, smooth muscle cell, Review, Energy homeostasis, 0302 clinical medicine, Chylomicrons, apo, apolipoprotein, GLP-2, glucagon-like peptide-2, TG, triglyceride, Chemistry, Gastroenterology, eNOS, endothelial nitric oxide synthase, VEGF-C, vascular endothelial growth factor C, MTP, microsomal triglyceride transfer protein, mRNA, messenger RNA, 3. Good health, Cell biology, Intestine, Plin, perilipin, medicine.anatomical_structure, PCTV, prechylomicron transport vesicle, VEGFR, vascular endothelial growth factor receptor, CLD, cytoplasmic lipid droplet, vSNARE, vesicle soluble NSF attachment protein receptor, Lymphatics, 030211 gastroenterology & hepatology, Lymph, Intracellular, SNARE, soluble NSF attachment protein receptor, Enterocyte, CRL, Calcitonin receptor-like receptor, Chylomicron, ER, endoplasmic reticulum, 03 medical and health sciences, medicine, Animals, Humans, Secretion, lcsh:RC799-869, Triglycerides, SDR39U1, short-chain dehydrogenase/reductase family 39U member 1, Lamina propria, NO, nitric oxide, ENS, enteric nervous system, Mucous Membrane, Hepatology, FA, fatty acid, VLDL, very-low-density lipoprotein, Biological Transport, STXBP5, syntaxin-binding protein 5, FABP, fatty acid binding protein, Lipid Metabolism, Dietary Fats, CM, chylomicron, 030104 developmental biology, MG, monoglyceride, GLP-2R, glucagon-like peptide-2 receptor, LCFA, long-chain fatty acid, lcsh:Diseases of the digestive system. Gastroenterology, Lipoprotein, Hormone |
| الوصف: | Rapid and efficient digestion and absorption of dietary triglycerides and other lipids by the intestine, the packaging of those lipids into lipoprotein chylomicron (CM) particles, and their secretion via the lymphatic duct into the blood circulation are essential in maintaining whole-body lipid and energy homeostasis. Biosynthesis and assembly of CMs in enterocytes is a complex multistep process that is subject to regulation by intracellular signaling pathways as well as by hormones, nutrients, and neural factors extrinsic to the enterocyte. Dysregulation of this process has implications for health and disease, contributing to dyslipidemia and a potentially increased risk of atherosclerotic cardiovascular disease. There is increasing recognition that, besides intracellular regulation of CM assembly and secretion, regulation of postassembly pathways also plays important roles in CM secretion. This review examines recent advances in our understanding of the regulation of CM secretion in relation to mobilization of intestinal lipid stores, drawing particular attention to post-assembly regulatory mechanisms, including intracellular trafficking of triglycerides in enterocytes, CM mobilization from the lamina propria, and regulated transport of CM by intestinal lymphatics. Keywords: Intestine, Chylomicron, Triglycerides, Lymphatics |
| اللغة: | English |
| تدمد: | 2352-345X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a8e6ffc9f932c553f64c323df06787Test http://europepmc.org/articles/PMC6396431Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f8a8e6ffc9f932c553f64c323df06787 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2352345X |
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