التفاصيل البيبلوغرافية
| العنوان: |
A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression |
| المؤلفون: |
Fitzgerald, Paul B., Mellow, Tessa B., Hoy, Kate E., Segrave, Rebecca, Cooper, Nicholas R., Upton, Daniel J., Croft, Rodney J. |
| المساهمون: |
Swinburne University of Technology |
| المصدر: |
Journal of Affective Disorders, Vol. 117, no. 3 (Oct 2009), pp. 212-216 |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2009 |
| مصطلحات موضوعية: |
psy, socio |
| الوصف: |
Background: Major Depressive Disorder is widely recognised to be a heterogeneous syndrome with numerous depressive phenotypes, one of which is melancholic depression. Patients with melancholic depression exhibit treatment responses and outcomes that differ from patients with non-melancholic depression. The current study aimed to assess whether differences existed between melancholic and non-melancholic subtypes of depression, as measured by the event related potential, intensity dependence of the auditory evoked potential (IDAEP). Methods: IDAEP was assessed in 14 melancholic and 13 non-melancholic depressed subjects and 14 controls. Results: The melancholic patients had a significantly shallower IDAEP slope than the non-melancholic patients not explained by depression severity or age. Limitations: Antidepressants were taken by all patients in this study and the effect of continual use of these drugs on the IDAEP slopes has yet to be confirmed. Conclusions: These results provide support for neurobiological differences between melancholic and non-melancholic depressive subtypes. Melancholic depression may be characterized by ongoing over function of the serotonin system in spite of medication treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
http://hdl.handle.net/1959.3/49790Test |
| الإتاحة: |
http://hdl.handle.net/1959.3/49790Test |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.1AB09725 |
| قاعدة البيانات: |
BASE |
