Bidirectional associations between treatment-resistant depression and general medical conditions
| العنوان: | Bidirectional associations between treatment-resistant depression and general medical conditions |
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| المؤلفون: | Liselotte Petersen, Preben Bo Mortensen, Bartholomeus C M Haarman, Hemmo A. Drexhage, Natalie C. Momen, Kathrine Bang Madsen, John J. McGrath, Oleguer Plana-Ripoll, Trine Munk-Olsen |
| المساهمون: | Immunology, Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| المصدر: | European Neuropsychopharmacology, 51, 7-19. Elsevier Bidirectional associations between treatment-resistant depression and general medical conditions Bang Madsen, K, Momen, N C, Petersen, L V, Plana-Ripoll, O, Haarman, B C M, Drexhage, H, Mortensen, P B, McGrath, J J & Munk-Olsen, T 2021, ' Bidirectional associations between treatment-resistant depression and general medical conditions ', European Neuropsychopharmacology, vol. 51, pp. 7-19 . https://doi.org/10.1016/j.euroneuro.2021.04.021Test European Neuropsychopharmacology, 51, 7-19. ELSEVIER SCIENCE BV |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Register-based study, Cohort Studies, Depressive Disorder, Treatment-Resistant, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, Odds Ratio, Humans, Medicine, Pharmacology (medical), In patient, Medical prescription, Biological Psychiatry, Depression (differential diagnoses), Population-based study, Pharmacology, Depression, business.industry, Proportional hazards model, Hazard ratio, Antidepressants, Odds ratio, medicine.disease, Antidepressive Agents, 030227 psychiatry, Psychiatry and Mental health, General medical conditions, Neurology, Migraine, Female, Neurology (clinical), Treatment-resistant depression, business, 030217 neurology & neurosurgery |
| الوصف: | Depression is associated with general medical conditions (GMCs), but it is not known if treatment-resistant depression (TRD) affects GMC risk and vice versa. We estimated bidirec-tional associations between TRD and GMCs (prior and subsequent). All individuals aged 18-69 years, born and living in Denmark, with a first-time prescription for an antidepressant between 2005 and 2012 were identified in the Danish Prescription Registry ( N = 154,513). TRD was de -fined as at least two shifts in treatment regimes. For prior GMCs, we estimated odds ratios (ORs) using conditional logistic regression comparing TRD patients with matched non-TRD controls adjusted for other GMCs and number of other GMCs. For subsequent GMCs, we used Cox regression to calculate hazard ratios (HRs) in TRD vs. non-TRD patients adjusted for age at first prescription, calendar time, other GMCs and number of other GMCs. Patients with TRD had higher prevalence of prior GMCs related to the immune or neurological systems; musculoskeletal disorders (women aOR: 1.35, 95% CI: 1.26-1.46, men aOR: 1.30, 95% CI: 1.19-1.42) and migraine (women aOR: 1.22, 95% CI: 1.09-1.36, men aOR: 1.25, 95% CI: 1.00-1.56). Subsequent GMCs were related to a broader spectrum; cardiovascular (women aHR: 1.43, 95% CI: 1.32-1.54, men aHR: 1.31, 95% CI: 1.19-1.43), endocrine (women aHR: 1.52, 95% CI: 1.37-1.67, men aHR: 1.24, 95% CI: 1.07-1.44), and neurological disorders (women aHR: 1.24, 95% CI: 1.13-1.35, men aHR: 1.19, 95% CI: 1.07-1.34). Our study presents a broad overview of comorbid medical conditions in patients with TRD and further studies are needed to explore the associations in detail. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0Test/ ) |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1873-7862 0924-977X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33245ea4620c0fd63829fcf058e68474Test https://doi.org/10.1016/j.euroneuro.2021.04.021Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....33245ea4620c0fd63829fcf058e68474 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18737862 0924977X |
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