دورية أكاديمية
Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study
| العنوان: | Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study |
|---|---|
| المؤلفون: | Esbjörnsson, J, Månsson, F, Kvist, A, Da Silva, Z, Andersson, S, Fenyö, E, Isberg, P, Biague, A, Lindman, J, Palm, A, Rowland-Jones, S, Jansson, M, Medstrand, P, Norrgren, H, Group, Sweden And Guinea-Bissau Cohort Research |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Background HIV type 2 (HIV-2) is considered more benign and has fewer pathogenic consequences than HIV type 1 (HIV-1) for most infected individuals. However, reliable estimates of time to AIDS and mortality among those with HIV-2 infection are absent. We therefore aimed to compare the time to AIDS and mortality, and the CD4 T-cell dynamics between those infected with HIV-1 and HIV-2. Methods We did a prospective open cohort study. We included all police officers with regular employment from police stations in both urban and rural areas of Guinea-Bissau since Feb 6, 1990. We continued to include participants until Sept 28, 2009, and follow-up of HIV-1-positive and HIV-2-positive individuals continued until Sept 28, 2013. We collected blood samples at enrolment and at scheduled annual follow-up visits at police stations. We analysed longitudinal data from individuals infected with HIV-1 and HIV-2 according to time to AIDS, time to death, and T-cell dynamics. Time of HIV infection was estimated as the mid-timepoint between last HIV-seronegative and first HIV-seropositive sample. Data from an additional 2984 HIV-uninfected individuals from the same population were analysed to assess the effect of natural mortality on HIV-related mortality. Findings 872 participants tested HIV positive during the 23-year study period: 408 were infected with HIV-1 (183 infected before and 225 infected after enrolment) and 464 were infected with HIV-2 (377 before and 87 after enrolment). The median time from HIV infection to development of AIDS was 6·2 years (95% CI 5·4–7·1) for HIV-1 infection and 14·3 years (10·7–18·0) for HIV-2 infection (p<0·0001). The median survival time after HIV infection was 8·2 years (95% CI 7·5–8·9) for HIV-1 infection and 15·6 years (12·0–19·2) for HIV-2 infection (p<0·0001). Individuals who were infected with HIV-1 or HIV-2 before enrolment showed similar results. Comparison with uninfected individuals indicated limited confounding contribution from natural mortality. Mean CD4 percentages were higher ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:beb9a427-4ef6-47ac-a0cb-595f561f4290Test; https://doi.org/10.1016/s2352-3018Test(18)30254-6 |
| DOI: | 10.1016/s2352-3018(18)30254-6 |
| الإتاحة: | https://doi.org/10.1016/s2352-3018Test(18)30254-6 https://ora.ox.ac.uk/objects/uuid:beb9a427-4ef6-47ac-a0cb-595f561f4290Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5FC06E19 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/s2352-3018(18)30254-6 |
|---|