المؤلفون: Sara Del Tufo, Umberto Atripaldi, Antonella Nicastro, Iacopo Panarese, Davide Ciardiello, Valerio Nardone, Francesco Selvaggi, Roberto Grassi, Salvatore Cappabianca, Erika Martinelli, Alfonso Reginelli

المصدر: Radiology Case Reports, Vol 19, Iss 9, Pp 3626-3630 (2024)

مصطلحات موضوعية: Rectal cancer, Biomarkers, Perineural invasion, MRI, Staging, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Treatment of rectal cancer has improved over the years thanks to a multidisciplinary approach. A correct staging has a fundamental role for risk stratification and to define the best treatment for each patient. Unfortunately, approximately 30% of patients with locally advanced rectal cancers will experience tumor recurrence. Thus, the identification of novel clinical-pathological and radiological prognostic factors represents an urgent unmet clinical need. Here we report the case of a patient with radically resected localized rectal cancer who developed an impressive early pelvic recurrence. To better understand the clinical scenario, we have studied the possible factors related to the aggressiveness of the disease. The only poor prognosticfactor that was evidenced at histological report was perineural invasion. Therefore, we questioned whether we could evaluate perineural invasion with imaging, similar to head and neck tumors. Learning from this clinical case, we believe that improving the risk stratification and radiology reporting is necessary to provide the best care for the patient and allow for a better prognosis prediction. Of course, our data should be considered as hypothesis generating and should be further investigated and validated in larger and prospective studies.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S193004332400428XTest; https://doaj.org/toc/1930-0433Test

الوصول الحر: https://doaj.org/article/eec5cbb29fdd4342a5a6cb660c4ec7b4Test

المؤلفون: Federico Gagliardi, Anna Russo, Camila Scharf, Alessandro Pinto, Mario Faenza, Emma D'Ippolito, Giuseppe Argenziano, Teresa Troiani, Alfonso Reginelli, Valerio Nardone

المصدر: Clinical and Translational Radiation Oncology, Vol 46, Iss , Pp 100774- (2024)

مصطلحات موضوعية: non-melanoma skin cancer (NMSC), Radiotherapy, high-frequency ultrasound (HFUS), Dermascopy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: This series introduces the clinical management of difficult-to-treat non-melanoma skin cancers (NMSCs) through a multidisciplinary approach, emphasizing the integration of dermoscopy and Ultra high-frequency ultrasound (UHFUS) for accurate diagnosis and treatment planning, particularly in cases referred for radiotherapy (RT). Dermoscopy aids in diagnosing both pigmented and non-pigmented skin lesions, guiding treatment margins and reducing the benign-to-malignant biopsy ratio. UHFUS provides valuable insights into tumor size, depth, and vascularity, complementing clinical evaluations and assisting in RT planning. Three challenging cases are presented, highlighting the pivotal role of dermoscopy and UHFUS in decision-making and treatment optimization. Collaboration between dermatologists, radiation oncologists, and radiologists enhances diagnostic accuracy, tailoring treatment plans to individual patient needs and preferences, ultimately improving patient outcomes and experience. The integration of these imaging techniques holds promise for optimizing non-surgical treatments like RT and monitoring treatment progress, offering a personalized approach to NMSC management.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S240563082400051XTest; https://doaj.org/toc/2405-6308Test

الوصول الحر: https://doaj.org/article/094cfcff06fa4d50bd08b90f03d08d78Test

المؤلفون: B. De Devitiis, F. Bimbo, R. Viscecchia, G. Nardone, A. Seccia, L. Monacis, M. Albenzio, A. Santillo

المصدر: Journal of Dairy Science, Vol 106, Iss 12, Pp 8469-8478 (2023)

مصطلحات موضوعية: sheep milk yogurt, consumer acceptance, willingness to buy, multivariate logistic regression, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250

الوصف: ABSTRACT: Testing consumer acceptance for a new product, such as the sheep milk–based yogurt, provides a measure of its market success, thus it informs producers on the effectiveness of their decision to transform sheep milk into yogurt to increase their revenues. This work explores to what extent consumers accept sheep milk–based yogurt and tests the role of personal-related factors and product-related features on shaping its acceptance. The study collects data from a representative sample of Italian yogurt consumers, and data are then analyzed via a logistic regression. Results show that male, highly educated, and high-income consumers are more likely than others to accept sheep milk–based yogurt. Findings suggest that consumers' food neophobia and variety seeking traits play a pivotal role in affecting consumer acceptance. Lastly, interest in nutritional and health-related yogurt features increases the probability of accepting sheep milk–based yogurt. Thus, sheep milk–based yogurt should be targeted at high-end male consumers and those interested in nutritional and health-related aspects of yogurt. Informing consumers about the sheep milk yogurt properties may further increase its acceptance and curb food neophobia, which we found to be one of the main barriers for the product acceptance. Future studies will explore consumer acceptance by using a real product and taste experiments.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0022030223005969Test; https://doaj.org/toc/0022-0302Test

الوصول الحر: https://doaj.org/article/85d8b555d8bd4a57b17268ed11cb5191Test

المؤلفون: Loreta A. Kondili, Giuseppina Brancaccio, Maria Elena Tosti, Barbara Coco, Maria Giovanna Quaranta, Vincenzo Messina, Alessia Ciancio, Filomena Morisco, Valentina Cossiga, Ernesto Claar, Valerio Rosato, Marianna Ciarallo, Irene Cacciola, Francesca Romana Ponziani, Lucia Cerrito, Roberta Coppola, Francesco Longobardi, Elisa Biliotti, Alessia Rianda, Francesco Barbaro, Nicola Coppola, Maria Stanzione, Francesco Barchiesi, Stefano Fagiuoli, Mauro Viganò, Marco Massari, Francesco Paolo Russo, Alberto Ferrarese, Diletta Laccabue, Vito Di Marco, Pierluigi Blanc, Aldo Marrone, Giulia Morsica, Alessandro Federico, Donatella Ieluzzi, Alba Rocco, Francesco Giuseppe Foschi, Alessandro Soria, Ivana Maida, Luchino Chessa, Michele Milella, Elena Rosselli Del Turco, Salvatore Madonia, Liliana Chemello, Ivan Gentile, Pierluigi Toniutto, Matteo Bassetti, Lorenzo Surace, Leonardo Baiocchi, Adriano Pellicelli, Adriano De Santis, Massimo Puoti, Elisabetta Degasperi, Grazia Anna Niro, Anna Linda Zignego, Antonio Craxi, Giovanni Raimondo, Teresa Antonia Santantonio, Maurizia Rossana Brunetto, Giovanni Battista Gaeta, Alessio Aghemo, Chiara Baiguera, Pier Maria Battezzati, Sara Battistella, Maria Grazia Bavetta, Costanza Bertoni, Carolina Boni, Paola Brambilla, Antonella Bray, Federica Briano, Enrico Carmenini, Francesco Castelli, Luisa Cavalletto, Federica Cerini, Luciana Chidichimo, Elisa Colella, Giuliana Cologni, Silvia Como, Romina Corsini, Chiara Costa, Rosa Cotugno, Silvia Cretella, Fernando De Angelis, Pasqualina De Leo, Giovanni Di Perri, Elisabetta Falbo, Luigina Ferrigno, Ezio Fornasiere, Daniela Francisci, Pietro Gatti, Pietro Lampertico, Ilaria Lenci, Anna Licata, Alfredo Marzano, Antonio Mastroianni, Cesare Mazzaro, Monica Monti, Gerardo Nardone, Laura Ambra Nicolini, Nicola Passigato, Maria Bruna Pasticci, Piera Pierotti, Biagio Pinchera, Teresa Pollicino, Carmen Porcu, Giulia Quartini, Gabriele Rancatore, Mario Romeo, Maria Grazia Rumi, Annalisa Saracino, Ornella Schioppa, Ilaria Serio, Roberta Soffredini, Xhimi Tata, Marco Tizzani, Matteo Tonnini, Carlo Torti, Daniela Valenti, Serena Zaltron, Alessia Zoncada

المصدر: International Journal of Infectious Diseases, Vol 146, Iss , Pp 107115- (2024)

مصطلحات موضوعية: Cohort, IFN treatment, Comorbidities, Infectious and parasitic diseases, RC109-216

الوصف: Background and Aims: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility. Methods: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model. Results: Of 5492 HBsAg-positive enrolled patients, 4152 (75.6%) were screened for HDV, 422 (10.2%) were anti-HDV positive. Compared with HBsAg mono-infected, anti-HDV positive patients were more often younger, non-Italians, with a history of drug use, had elevated alanine transaminase (ALT), cirrhosis, or hepatocellular carcinoma (HCC). Compared with Italians, anti-HDV positive non-Italians were younger (42.2% age ≤ 40 years vs. 2.1%; P < 0.001), more often females (males 43.0% vs. 68.6%; P < 0.001) with less frequent cirrhosis and HCC. HDV-RNA was detected in 63.2% of anti-HDV-positive patients, who were more likely to have elevated ALT, cirrhosis, and HCC. Extrahepatic comorbidities were present in 47.4% of anti-HDV positive patients and could affect the eligibility of IFN-containing therapies in at least 53.0% of patients in care. Conclusions: CHD affects young, foreign-born patients and older Italians, of whom two-thirds had cirrhosis or HCC. Comorbidities were frequent in both Italians and non-Italians and impacted eligibility for IFN.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1201971224001863Test; https://doaj.org/toc/1201-9712Test

الوصول الحر: https://doaj.org/article/d176c063bea340bc95d90a2a253e2009Test

المؤلفون: Phelps, NH, Singleton, RK, Zhou, B, Heap, RA, Mishra, A, Bennett, JE, Paciorek, CJ, Lhoste, VPF, Carrillo-Larco, RM, Stevens, GA, Rodriguez-Martinez, A, Bixby, H, Bentham, J, Di Cesare, M, Danaei, G, Rayner, AW, Barradas-Pires, A, Cowan, MJ, Savin, S, Riley, LM, Aguilar-Salinas, CA, Baker, JL, Barkat, A, Bhutta, ZA, Branca, F, Caixeta, RB, Cuschieri, S, Farzadfar, F, Ganapathy, S, Ikeda, N, Iotova, V, Kengne, AP, Khang, Y-H, Laxmaiah, A, Lin, H-H, Ma, J, Mbanya, JCN, Miranda, JJ, Pradeepa, R, Rodríguez-Artalejo, F, Sorić, M, Turley, M, Wang, L, Webster-Kerr, K, Aarestrup, J, Abarca-Gómez, L, Abbasi-Kangevari, M, Abdeen, ZA, Abdrakhmanova, S, Abdul Ghaffar, S, Abdul Rahim, HF, Abdurrahmonova, Z, Abu-Rmeileh, NM, Abubakar Garba, J, Acosta-Cazares, B, Adam, I, Adamczyk, M, Adams, RJ, Adu-Afarwuah, S, Aekplakorn, W, Afsana, K, Afzal, S, Agbor, VN, Agdeppa, IA, Aghazadeh-Attari, J, Ågren, Å, Aguenaou, H, Agyemang, C, Ahmad, MH, Ahmad, NA, Ahmadi, A, Ahmadi, N, Ahmed, I, Ahmed, SH, Ahrens, W, Aitmurzaeva, G, Ajlouni, K, Al-Hazzaa, HM, Al-Hinai, H, Al-Lahou, B, Al-Lawati, JA, Al-Raddadi, R, Al Asfoor, D, Al Hourani, HM, Al Qaoud, NM, Alarouj, M, AlBuhairan, F, AlDhukair, S, Aldwairji, MA, Alexius, S, Ali, MM, Alieva, AV, Alkandari, A, Alkerwi, A, Alkhatib, BM, Allin, K, Alomary, SA, Alomirah, HF, Alshangiti, AM, Alvarez-Pedrerol, M, Aly, E, Amarapurkar, DN, Amiano Etxezarreta, P, Amoah, J, Amougou, N, Amouyel, P, Andersen, LB, Anderssen, SA, Androutsos, O, Ängquist, L, Anjana, RM, Ansari-Moghaddam, A, Anufrieva, E, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arku, RE, Arlappa, N, Aryal, KK, Assefa, N, Aspelund, T, Assah, FK, Assembekov, B, Assunção, MCF, Aung, MS, Aurélio de Valois, CJM, Auvinen, J, Avdičová, M, Avi, S, Azad, K, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Babu, BV, Bacopoulou, F, Bæksgaard Jørgensen, M, Baharudin, A, Bahijri, S, Bajramovic, I, Bakacs, M, Balakrishna, N, Balanova, Y, Bamoshmoosh, M, Banach, M, Banegas, JR, Baran, J, Baran, R, Barbagallo, CM, Barbosa Filho, V, Barceló, A, Baretić, M, Barnoya, J, Barrera, L, Barreto, M, Barros, AJD, Barros, MVG, Bartosiewicz, A, Basit, A, Bastos, JL, Bata, I, Batieha, AM, Batista, AP, Batista, RL, Battakova, Z, Baur, LA, Bayauli, PM, Beaglehole, R, Bel-Serrat, S, Belavendra, A, Ben Romdhane, H, Benedek, T, Benedics, J, Benet, M, Benitez Rolandi, GE, Benzeval, M, Bere, E, Berger, N, Bergh, IH, Berhane, Y, Berkinbayev, S, Bernabe-Ortiz, A, Bernotiene, G, Berrios Carrasola, X, Bettiol, H, Beutel, ME, Beybey, AF, Bezerra, J, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, H, Bi, Y, Bia, D, Biasch, K, Bika Lele, EC, Bikbov, MM, Bista, B, Bjelica, DJ, Bjerregaard, AA, Bjerregaard, P, Bjertness, E, Bjertness, MB, Björkelund, C, Bloch, KV, Blokstra, A, Blychfeld Magnazu, M, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boer, JMA, Boggia, JG, Bogova, E, Boissonnet, CP, Bojesen, SE, Bonaccio, M, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Botomba, S, Bourne, RRA, Bovet, P, Boymatova, K, Braeckevelt, L, Braeckman, L, Bragt, MCE, Braithwaite, T, Brajkovich, I, Breckenkamp, J, Breda, J, Brenner, H, Brewster, LM, Brian, GR, Briceño, Y, Brinduse, L, Bringolf-Isler, B, Brito, M, Brophy, S, Brug, J, Bruno, G, Bugge, A, Buoncristiano, M, Burazeri, G, Burns, C, Cabrera de León, A, Cacciottolo, J, Cai, H, Cama, T, Cameron, C, Camolas, J, Can, G, Cândido, APC, Cañete, F, Capanzana, MV, Čapková, N, Capuano, E, Capuano, R, Capuano, V, Cardol, M, Cardoso, VC, Carlsson, AC, Carmuega, E, Carvalho, J, Casajús, JA, Casanueva, FF, Casas, M, Celikcan, E, Censi, L, Cervantes-Loaiza, M, Cesar, JA, Chamnan, P, Chamukuttan, S, Chan, A, Chan, Q, Charchar, FJ, Charles, M-A, Chaturvedi, HK, Chaturvedi, N, Che Abdul Rahim, N, Chee, ML, Chen, C-J, Chen, F, Chen, H, Chen, L-S, Chen, S, Chen, Z, Cheng, C-Y, Cheng, YJ, Cheraghian, B, Chetrit, A, Chikova-Iscener, E, Chinapaw, MJM, Chinnock, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Chirlaque, M-D, Cho, B, Christensen, K, Christofaro, DG, Chudek, J, Cifkova, R, Cilia, M, Cinteza, E, Cirillo, M, Claessens, F, Clare, P, Clarke, J, Clays, E, Cohen, E, Cojocaru, CR, Colorado-Yohar, S, Compañ-Gabucio, L-M, Concin, H, Confortin, SC, Cooper, C, Coppinger, TC, Corpeleijn, E, Cortés, LY, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crampin, AC, Cross, AJ, Crujeiras, AB, Cruz, JJ, Csányi, T, Csilla, S, Cucu, AM, Cui, L, Cureau, FV, Czenczek-Lewandowska, E, D'Arrigo, G, d'Orsi, E, da Silva, AG, Dacica, L, Dahm, CC, Dallongeville, J, Damasceno, A, Damsgaard, CT, Dankner, R, Dantoft, TM, Dasgupta, P, Dastgiri, S, Dauchet, L, Davletov, K, de Assis Guedes de Vasconcelos, F, de Assis, MAA, De Backer, G, De Bacquer, D, De Bacquer, J, de Bont, J, De Curtis, A, de Fragas Hinnig, P, de Gaetano, G, De Henauw, S, De Miguel-Etayo, P, De Neve, J-W, Duarte de Oliveira, P, De Ridder, D, De Ridder, K, de Rooij, SR, de Sá, ACMGN, De Smedt, D, Deepa, M, Deev, AD, DeGennaro, VJ, Delisle, H, Delpeuch, F, Demarest, S, Dennison, E, Dereń, K, Deschamps, V, Devrishov, RD, Dhimal, M, Di Castelnuovo, A, Dias-da-Costa, JS, Díaz-Sánchez, ME, Diaz, A, Díaz Fernández, P, Díez Ripollés, MP, Dika, Z, Djalalinia, S, Djordjic, V, Do, HTP, Dobson, AJ, Dominguez, L, Donati, MB, Donfrancesco, C, Dong, G, Dong, Y, Donoso, SP, Döring, A, Dorobantu, M, Dorosty, AR, Dörr, M, Doua, K, Dragano, N, Drygas, W, Du, S, Duan, JL, Duante, CA, Duboz, P, Duleva, VL, Dulskiene, V, Dumith, SC, Dushpanova, A, Dwyer, T, Dyussupova, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Ebrahimi, N, Echeverría, G, Eddie, R, Eftekhar, E, Efthymiou, V, Egbagbe, EE, Eggertsen, R, Eghtesad, S, Eiben, G, Ekelund, U, El-Khateeb, M, El Ammari, L, El Ati, J, Eldemire-Shearer, D, Elliott, P, Enang, O, Endevelt, R, Engle-Stone, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Eriksson, JG, Escobedo-de la Peña, J, Eslami, S, Esmaeili, A, Evans, A, Evans, RG, Faeh, D, Fagherazzi, G, Fakhradiyev, I, Fakhretdinova, AA, Fall, CH, Faramarzi, E, Farjam, M, Farrugia Sant'Angelo, V, Farzi, Y, Fattahi, MR, Fawwad, A, Fawzi, WW, Felix-Redondo, FJ, Ferguson, TS, Fernandes, RA, Fernández-Bergés, D, Ferrante, D, Ferrao, T, Ferrari, G, Ferrari, M, Ferrario, MM, Ferreccio, C, Ferreira, HS, Ferrer, E, Ferrieres, J, Figueiró, TH, Fijalkowska, A, Fink, G, Fisberg, M, Fischer, K, Foo, LH, Forsner, M, Fottrell, EF, Fouad, HM, Francis, DK, Franco, MDC, Fras, Z, Fraser, B, Frontera, G, Fuchs, FD, Fuchs, SC, Fujiati, II, Fujita, Y, Fumihiko, M, Furdela, V, Furusawa, T, Gabriela, SA, Gaciong, Z, Gafencu, M, Galán Cuesta, M, Galbarczyk, A, Galcheva, SV, Galenkamp, H, Galeone, D, Galfo, M, Galvano, F, Gao, J, Gao, P, Garcia-de-la-Hera, M, García Mérida, MJ, García Solano, M, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gaya, ACA, Gaya, AR, Gazzinelli, A, Gehring, U, Geiger, H, Geleijnse, JM, George, R, Gerdts, E, Ghaderi, E, Ghamari, S-H, Ghanbari, A, Ghasemi, E, Gheorghe-Fronea, O-F, Gialluisi, A, Giampaoli, S, Gianfagna, F, Gieger, C, Gill, TK, Giovannelli, J, Gironella, G, Giwercman, A, Gkiouras, K, Glushkova, N, Godara, R, Godos, J, Gogen, S, Goldberg, M, Goltzman, D, Gómez, G, Gómez Gómez, JH, Gomez, LF, Gómez, SF, Gomula, A, Gonçalves Cordeiro da Silva, B, Gonçalves, H, Gonçalves, M, González-Alvarez, AD, Gonzalez-Chica, DA, González-Gil, EM, Gonzalez-Gross, M, González-Leon, M, González-Rivas, JP, González-Villalpando, C, González-Villalpando, M-E, Gonzalez, AR, Gottrand, F, Graça, AP, Grafnetter, D, Grajda, A, Grammatikopoulou, MG, Gregg, EW, Gregor, RD, Gregório, MJ, Grøholt, EK, Grøntved, A, Grosso, G, Gruden, G, Gu, D, Guajardo, V, Gualdi-Russo, E, Guallar-Castillón, P, Gualtieri, A, Gudmundsson, EF, Gudnason, V, Guerchet, M, Guerrero, R, Guessous, I, Guimaraes, AL, Gujral, UP, Gulliford, MC, Gunnlaugsdottir, J, Gunter, MJ, Guo, X-H, Guo, Y, Gupta, PC, Gupta, R, Gureje, O, Gurinović, MA, Gutiérrez González, E, Gutierrez, L, Gutzwiller, F, Gwee, X, Ha, S, Hadaegh, F, Hadjigeorgiou, CA, Haghshenas, R, Hakimi, H, Halkjær, J, Hambleton, IR, Hamzeh, B, Hanekom, WA, Hange, D, Hanif, AAM, Hantunen, S, Hao, J, Hardman, CM, Hardy, L, Hari Kumar, R, Harmer Lassen, T, Harooni, J, Hashemi-Shahri, SM, Hassapidou, M, Hata, J, Haugsgjerd, T, Hayes, AJ, He, J, He, Y, Heidinger-Felső, R, Heier, M, Heinen, M, Hejgaard, T, Hendriks, ME, Henrique, RDS, Henriques, A, Hernandez Cadena, L, Herrala, S, Herrera-Cuenca, M, Herrera, VM, Herter-Aeberli, I, Herzig, K-H, Heshmat, R, Heude, B, Hill, AG, Ho, SY, Ho, SC, Hobbs, M, Höfelmann, DA, Holdsworth, M, Homayounfar, R, Homs, C, Hoogendijk, E, Hopman, WM, Horimoto, ARVR, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MMT, Hu, Y, Huerta, JM, Huhtaniemi, IT, Huiart, L, Huidumac Petrescu, C, Husseini, A, Huu, CN, Huybrechts, I, Hwalla, N, Hyska, J, Iacoviello, L, Iakupova, EM, Ibarluzea, J, Ibrahim, MM, Ibrahim Wong, N, Igland, J, Ijoma, C, Ikram, MA, Iñiguez, C, Irazola, VE, Ishida, T, Isiguzo, GC, Islam, M, Islam, SMS, Islek, D, Ittermann, T, Ivanova-Pandourska, IY, Iwasaki, M, 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مصطلحات موضوعية: BF Psychology, TX341 Nutrition. Foods and food supply, RA0421 Public health. Hygiene. Preventive Medicine

الوصف: Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For school-aged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least ...

وصف الملف: text

العلاقة: https://researchonline.ljmu.ac.uk/id/eprint/22751/1/Worldwide%20trends%20in%20underweight%20and%20obesity%20from%201990%20to%202022.pdfTest; Phelps, NH, Singleton, RK, Zhou, B, Heap, RA, Mishra, A, Bennett, JE, Paciorek, CJ, Lhoste, VPF, Carrillo-Larco, RM, Stevens, GA, Rodriguez-Martinez, A, Bixby, H, Bentham, J, Di Cesare, M, Danaei, G, Rayner, AW, Barradas-Pires, A, Cowan, MJ, Savin, S, Riley, LM, Aguilar-Salinas, CA, Baker, JL, Barkat, A, Bhutta, ZA, Branca, F, Caixeta, RB, Cuschieri, S, Farzadfar, F, Ganapathy, S, Ikeda, N, Iotova, V, Kengne, AP, Khang, Y-H, Laxmaiah, A, Lin, H-H, Ma, J, Mbanya, JCN, Miranda, JJ, Pradeepa, R, Rodríguez-Artalejo, F, Sorić, M, Turley, M, Wang, L, Webster-Kerr, K, Aarestrup, J, Abarca-Gómez, L, Abbasi-Kangevari, M, Abdeen, ZA, Abdrakhmanova, S, Abdul Ghaffar, S, Abdul Rahim, HF, Abdurrahmonova, Z, Abu-Rmeileh, NM, Abubakar Garba, J, Acosta-Cazares, B, Adam, I, Adamczyk, M, Adams, RJ, Adu-Afarwuah, S, Aekplakorn, W, Afsana, K, Afzal, S, 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Tarqui-Mamani, CB, Taxová Braunerová, R, Taylor, A, Taylor, J, Tchibindat, F, Te Velde, S, Tebar, WR, Tell, GS, Tello, T, Tessema, M, Tham, YC, Thankappan, KR, Theobald, H, Theodoridis, X, Thomas, N, Thorand, B, Thrift, AG, Tichá, Ľ, Timmermans, EJ, Tjandrarini, DH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Tomaszewski, M, Topbas, M, Topór-Mądry, R, Torheim, LE, Tornaritis, MJ, Torrent, M, Torres-Collado, L, Toselli, S, Touloumi, G, Traissac, P, Tran, TT-H, Tremblay, MS, Triantafyllou, A, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tsigga, M, Tsintavis, P, Tsugane, S, Tuitele, J, Tuliakova, AM, Tulloch-Reid, MK, Tullu, F, Tuomainen, T-P, Tuomilehto, J, Twig, G, Tynelius, P, Tzala, E, Tzotzas, T, Tzourio, C, Udoji, N, Ueda, P, Ugel, E, Ukoli, FAM, Ulmer, H, Unal, B, Usupova, Z, Uusitalo, HMT, Uysal, N, Vaitkeviciute, J, Valdivia, G, Vale, S, Valvi, D, van Dam, RM, van den Born, B-J, Van der Heyden, J, van der Schouw, YT, Van Herck, K, Van Lippevelde, W, Van 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The Lancet, 403 (10431). pp. 1027-1050. ISSN 0140-6736

الإتاحة: https://doi.org/10.1016/s0140-6736Test(23)02750-2
http://researchonline.ljmu.ac.uk/id/eprint/22751Test/
https://researchonline.ljmu.ac.uk/id/eprint/22751/1/Worldwide%20trends%20in%20underweight%20and%20obesity%20from%201990%20to%202022.pdfTest

المؤلفون: Enrica Marchionni, Maria Rosaria D'Apice, Viviana Lupo, Giovanna Lattanzi, Elisabetta Mattioli, Gina Lisignoli, Elena Gabusi, Gerardo Pepe, Manuela Helmer Citterich, Elena Campione, Anna Maria Nardone, Paola Spitalieri, Noemi Pucci, Dario Cocciadiferro, Eliseo Picchi, Francesco Garaci, Antonio Novelli, Giuseppe Novelli

المصدر: Bone Reports, Vol 19, Iss , Pp 101728- (2023)

مصطلحات موضوعية: COL2A1, Type-II collagenopathies, Reverse-phenotyping, Exome sequencing, Functional characterization, Diseases of the musculoskeletal system, RC925-935

الوصف: COL2A1 gene encodes the alpha-1 chain of type-II procollagen. Heterozygous pathogenic variants are associated with the broad clinical spectrum of genetic diseases known as type-II collagenopathies. We aimed to characterize the NM_001844.5:c.1330G>A;p.Gly444Ser variant detected in the COL2A1 gene through trio-based prenatal exome sequencing in a fetus presenting a severe skeletal phenotype at 31 Gestational Weeks and in his previously undisclosed mild-affected father. Functional studies on father's cutaneous fibroblasts, along with in silico protein modeling and in vitro chondrocytes differentiation, showed intracellular accumulation of collagen-II, its localization in external Golgi vesicles and nuclear morphological alterations. Extracellular matrix showed a disorganized fibronectin network. These results showed that p.Gly444Ser variant alters procollagen molecules processing and the assembly of mature type-II collagen fibrils, according to COL2A1-chain disorganization, displayed by protein modeling. Clinical assessment at 38 y.o., through a reverse-phenotyping approach, revealed limp gait, short and stocky appearance. X-Ray and MRI showed pelvis asymmetry with severe morpho-structural alterations of the femoral heads bilaterally, consistent with a mild form of type-II collagenopathy. This study shows how the fusion of genomics and clinical expertise can drive a diagnosis supported by cellular and bioinformatics studies to effectively establish variants pathogenicity.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2352187223000748Test; https://doaj.org/toc/2352-1872Test

الوصول الحر: https://doaj.org/article/7aab59cb6a3344baa1cce4c1308ebddcTest

المؤلفون: Giuseppina Brancaccio, Barbara Coco, Alessandra Nardi, Maria Giovanna Quaranta, Maria Elena Tosti, Luigina Ferrigno, Irene Cacciola, Vincenzo Messina, Luchino Chessa, Filomena Morisco, Michele Milella, Francesco Barbaro, Alessia Ciancio, Francesco Paolo Russo, Nicola Coppola, Pierluigi Blanc, Ernesto Claar, Gabriella Verucchi, Massimo Puoti, Anna Linda Zignego, Liliana Chemello, Salvatore Madonia, Stefano Fagiuoli, Alfredo Marzano, Carlo Ferrari, Pietro Lampertico, Vito Di Marco, Antonio Craxì, Teresa Antonia Santantonio, Giovanni Raimondo, Maurizia R. Brunetto, Giovanni Battista Gaeta, Loreta A. Kondili, Luisa Pasulo, Carmine Coppola, Federica Pisano, Mariarosaria Romano, Carmen Porcu, Irene Francesca Bottalico, Valentina Cossiga, Xhimi Tata, Caterina Sagnelli, Piera Pierotti, Elisabetta Degasperi, Valerio Rosato, Lorenzo Badia, Dontella Ieluzzi, Monica Monti, Maria Grazia Bavetta, Luisa Cavalletto, Pierluigi Toniutto, Ezio Fornasiere, Antonio Colecchia, Alberto Ferrarese, Gerardo Nardone, Alba Rocco, Mauro Viganò, Francesco Giuseppe Foschi, Fabio Conti, Giulia Morsica, Stefania Salpietro, Carlo Torti, Chiara Costa, Alessandro Federico, Marcello Dallio, Alessia Giorgini, Marco Anselmo, Pasqualina De Leo, Serena Zaltron, Anna Cambianica, Fabio Piscaglia, Ilaria Serio, Simona Schivazappa, Antonio Mastroianni, Luciana Chidichimo, Marco Massari, Cesare Mazzaro, Aldo Marrone, Francesca Maria D'Amore, Gianpiero D'Offizi, Anna Licata, Grazia Anna Niro, Teresa Pollicino, Alessio Aghemo

المصدر: International Journal of Infectious Diseases, Vol 129, Iss , Pp 266-273 (2023)

مصطلحات موضوعية: Hepatitis B, Chronic, Hepatitis Delta, Epidemiology, Migrants, Hepatitis control, Infectious and parasitic diseases, RC109-216

الوصف: Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy. Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used. Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S120197122300053XTest; https://doaj.org/toc/1201-9712Test

الوصول الحر: https://doaj.org/article/7fccc43b31754953bda7d26ec504131eTest

المؤلفون: Nicola Reggidori, Laura Bucci, Valentina Santi, Benedetta Stefanini, Lorenzo Lani, Davide Rampoldi, Giorgia Ghittoni, Fabio Farinati, Alberto Masotto, Bernardo Stefanini, Andrea Mega, Elisabetta Biasini, Francesco Giuseppe Foschi, Gianluca Svegliati-Baroni, Angelo Sangiovanni, Claudia Campani, Giovanni Raimondo, Gianpaolo Vidili, Antonio Gasbarrini, Ciro Celsa, Mariella Di Marco, Edoardo G. Giannini, Rodolfo Sacco, Maurizia Rossana Brunetto, Francesco Azzaroli, Donatella Magalotti, Filomena Morisco, Gian Ludovico Rapaccini, Gerardo Nardone, Alessandro Vitale, Franco Trevisani, Maurizio Biselli, Paolo Caraceni, Annagiulia Gramenzi, Francesca Benevento, Alessandro Granito, Luca Muratori, Fabio Piscaglia, Francesco Tovoli, Gloria Allegrini, Calogero Cammà, Giuseppe Cabibbo, Carmelo Marco Giacchetto, Paolo Giuffrida, Maria Vittoria Grassini, Mauro Grova, Gabriele Rancatore, Caterina Stornello, Valentina Adotti, Tancredi Li Cavoli, Fabio Marra, Martina Rosi, Vittoria Bevilacqua, Alberto Borghi, Lucia Napoli, Fabio Conti, G.L. Frassineti, Maria Teresa Migliano, Nicoletta de Matthaeis, Francesca Romana Ponziani, Gabriele Missale, Andrea Olivani, Mario Capasso, Valentina Cossiga, Maria Guarino, Ester Marina Cela, Antonio Facciorusso, Camilla Graziosi, Valentina Lauria, Giorgio Pelecca, Marta Schirripa, Fabrizio Chegai, Armando Raso, Alessio Bozzi, Maria Stella Franzè, Carlo Saitta, Assunta Sauchella, Elton Dajti, Federico Ravaioli, Maria Corina Plaz Torres, Giulia Pieri, Filippo Oliveri, Gabriele Ricco, Veronica Romagnoli, Alessandro Inno, Fabiana Marchetti, Pietro Coccoli, Antonio Malerba, Alberta Cappelli, Rita Golfieri, Cristina Mosconi, Matteo Renzulli

المصدر: JHEP Reports, Vol 5, Iss 8, Pp 100784- (2023)

مصطلحات موضوعية: Hepatocellular carcinoma, Alcohol abuse, ITA.LI.CA staging system, Metabolic dysfunction-associated fatty liver disease, Surveillance programs, Oesophageal varices, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Background & Aims: Alcohol abuse and metabolic disorders are leading causes of hepatocellular carcinoma (HCC) worldwide. Alcohol-related aetiology is associated with a worse prognosis compared with viral agents, because of the lower percentage of patients diagnosed with HCC under routine surveillance and a higher burden of comorbidity in alcohol abusers. This study aimed to describe the evolving clinical scenario of alcohol-related HCC over 15 years (2006–2020) in Italy. Methods: Data from the Italian Liver Cancer (ITA.LI.CA) registry were used: 1,391 patients were allocated to three groups based on the year of HCC diagnosis (2006–2010; 2011–2015; 2016–2020). Patient characteristics, HCC treatment, and overall survival were compared among groups. Survival predictors were also investigated. Results: Approximately 80% of alcohol-related HCCs were classified as cases of metabolic dysfunction-associated fatty liver disease. Throughout the quinquennia,

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2589555923001155Test; https://doaj.org/toc/2589-5559Test

الوصول الحر: https://doaj.org/article/994809fcb7eb4d6c91173f05293807e2Test

المؤلفون: Xiaoyong Fu, Resel Pereira, Chia-Chia Liu, Carmine De Angelis, Martin J. Shea, Sarmistha Nanda, Lanfang Qin, Tamika Mitchell, Maria L. Cataldo, Jamunarani Veeraraghavan, Vidyalakshmi Sethunath, Mario Giuliano, Carolina Gutierrez, Balázs Győrffy, Meghana V. Trivedi, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Mothaffar F. Rimawi, C. Kent Osborne, Rachel Schiff

المصدر: Cell Reports, Vol 42, Iss 8, Pp 112821- (2023)

مصطلحات موضوعية: CP: Cancer, Biology (General), QH301-705.5

الوصف: Summary: Aberrant activation of the forkhead protein FOXA1 is observed in advanced hormone-related cancers. However, the key mediators of high FOXA1 signaling remain elusive. We demonstrate that ectopic high FOXA1 (H-FOXA1) expression promotes estrogen receptor-positive (ER+) breast cancer (BC) metastasis in a xenograft mouse model. Mechanistically, H-FOXA1 reprograms ER-chromatin binding to elicit a core gene signature (CGS) enriched in ER+ endocrine-resistant (EndoR) cells. We identify Secretome14, a CGS subset encoding ER-dependent cancer secretory proteins, as a strong predictor for poor outcomes of ER+ BC. It is elevated in ER+ metastases vs. primary tumors, irrespective of ESR1 mutations. Genomic ER binding near Secretome14 genes is also increased in mutant ER-expressing or mitogen-treated ER+ BC cells and in ER+ metastatic vs. primary tumors, suggesting a convergent pathway including high growth factor receptor signaling in activating pro-metastatic secretome genes. Our findings uncover H-FOXA1-induced ER reprogramming that drives EndoR and metastasis partly via an H-FOXA1/ER-dependent secretome.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S221112472300832XTest; https://doaj.org/toc/2211-1247Test

الوصول الحر: https://doaj.org/article/9ae29d74241a427e80d1e8022dc30c52Test

المؤلفون: Alexandra Compagnucci, Man K. Chan, Yacine Saïdi, Tim R. Cressey, Alasdair Bamford, Yoann Riault, Alexandra Coelho, Aoife Nolan, Suwalai Chalermpantmetagul, Gabija Morkunaite, Pauline Amuge, Victor Musiime, Avy Violari, Mark Cotton, Adeodata R. Kekitiinwa, Elizabeth Kaudha, Marisa Groenewald, Afaaf A. Liberty, Suparat Kanjanavanit, Alla Volokha, Rosa Bologna, Noris Pavia Ruz, Luis Prieto Tato, Paolo Paioni, Laura Marques, Véronique Reliquet, Tim Niehues, Steven B. Welch, Deborah Ford, Carlo Giaquinto, Diana M. Gibb, Abdel Babiker, Jose Tomas Ramos Amador, A. Compagnucci, Y. Saidi, Y. Riault, A. Coelho, C. Kouakam, L. Picault, M. Ndiaye, L. Meyer, C. Cagnot, S. Circosta, L. Léger, S. Simanic, A. Arulananthan, D.M. Gibb, A. Babiker, M. Chan, D. Ford, F. Hudson, L. Harper, A. Bamford, A. Nolan, K. Widuch, S. Townsend, N. Van-Looy, L. Gao, E. Little, A. Turkova, S. Fabiane, J. Calvert, J. Blackstone, K. Scott, J. Inshaw, A. Nunn, A. Nardone, D. Bilardi, T.R. Cressey, S. Chalermpantmetagul, W. Khamduang, G. Jourdain, N. Ngo Giang Huong, D. Chinwong, C. Saenjum, R. Peongjakta, P. Sukrakanchana, L. Laomanit, A. Kaewbundit, J. Khamkon, K. Than-in-at, C. Meeboon, W. Sripaoraya, N. Krueduangkam, N. Kruenual, W. Khamjakkaew, S. Klinprung, C. Giaquinto, G. Morkunaite, D. Hirt, L. Prieto Tato, T. Niehues, D. Plonné, C. Morén, T. Noguera, M.A. Muñoz Fernández, R. Bologna, S. Arazi, A.G. Fedullo, M. Taicz, E. Vicentini, M. Moragas, A. Mangano, M. Dell’Orso, M. Gatto, V. Reliquet, A. Soria, E. Paredes, N. Chereau, M. Tching Sin, L. Flet, A. Rodallec, C. Hemon, N. Elenga, M.D. Terrine, N. Blaise, S. Augustin, P. Mespoulhe, H. Pouchain, N. Pavia-Ruz, R. Muñoz- Hernández, A. Neri-Macias, M.D. Jarillo-Quijada, C. Espinosa-Sotero, L. Marques, C. Teixeira, A. Fernandes, R. Nunes, H. Nascimento, J. Tuna, A. Padrao, I. Ferraz, A.C. Mendes, C. Correira, H. Pinheiro, A.C. Matos, A.C. Sampaio, A. Oliveira, A. Caldeira, M. Tavares, A. Reis Melo, C. Castro, C. Faria, C. Prucha, R. Ribeiro, F. Monteiro, M.F. Candeias, T. Silva Milhiero, E. Gomes Neves, R. Corte-Real, M. Morgado, D. Mendes, M. Cardão, A. Violari, N. Ramsagar, A. Liberty, M. Nyati, L. Maseko, M. Khunene, S. Mkhize, Z. Essack, N. Akoojee, U. Singh, Y. Fourie, S. Govender, A. Vadee, R. Lakha, J. Erasmus, A. Mamiane, T. Daniel, P. Bhana, N. Maduna, M. Cotton, M. Groenewald, G. Slade, J. Coetzee, L. Ganger, S. Weldon, M. Wessels, L. Hoorn, S. Pieterse, C. Makola, K. Smith, M. Isaacs, A. Cweya, S. Fry, S. Barnabas, M. Theunissen, N. Nduna, M. Smuts, P. Rojo Conejo, C. Epalza, M. Fernández, M.J. Mellado Peña, T. Sainz Costa, L. Escosa García, P. Gomez Salcedo, C. Fortuny Guasch, T. Noguera Julian, C. Estepa, M. Cubells, E. Sans, E. Bruno, L. Prieto, P. Mendez García, A. Murciano Cabeza, M. Coto, R. Torrent, M. Torres Arauz, M. Navarro Gómez, A. Mur, S. Guillén Martin, M. Moreno, J.T. Ramos Amador, I. Garcia, C. Kalhert, T. Wachinger, B. Wohlwend, S. Hafner, G. Dollenmaier, P. Paioni, R. Signorell, J. Boni, A. Duppenthaler, B. Mann, C. Saegesser, M. Barbani, C. Ngampiyaskul, P. Greetanukroh, P. Khannak, P. Tearsansern, W. Chamjamrat, N. Chanto, T. Thapwai, K. Thungkham, P. Puangmalai, C. Ruklao, P. Ounchanum, S. Khusuwan, S. Denjanta, Y. Thaweesombat, J. Thewsoongnoen, K. Kaewmamueng, P. Kamboua, S. Pongprapass, W. Srisuk, A. Kongponoi, J. Limplertjareanwanich, S. Kanjanavanit, C. Saewtrakool, P. Yingyong, D. Chutima, R. Junkaew, T. Chankun, U. Srirompotong, P. Sudsaard, K. Kongsuk, T. Petpranee, S. Srirojana, D. Donngernl, A. Kamkoonmongkol, N. Na Kalasin, P. Phunkhum, A.R. Kekitiinwa, P. Amuge, D. Bbuye, J. Nalubwama, S. Namanda, M. Nsibuka Kisekka, A. Kirabira, L. Lawrence, G. Agaba, G. Ahimbisibwe, A. Nalugo, F. Namuli, R. Kadhuba, R. Namuddu, I. Nabwire, L. Kiyimba, A. Baita, J. Tikabibamu, L. Nakandi, G.P. Kisitu, N. Nabukeera Barung, C.M. Kityo, V. Musiime, E. Kaudha, A. Nanduudu, E. Mujyambere, S.P. Labeja Ocitti, J. Ategeka, E. Nambi, R. Nazzinda, D. Rutebarika, R. Basiimwa, R. Mbabazi, P. Kyobutungi, M. Nabalamba, A. Nakalyango, J. Tumusiime, S. Nakabuye, J. Mwebaza, S. Oruk, J. Namusanje, A. Musiime, L. Mugarura, M. Ojok, J. Kitabalwa, C. Katemba, M. Nannungi, E. Bagirigomwa, D. Odoch, E. Rubanga, D. Mulima, E.L. Babu, D. Baliruno, C. Inyakuwal, E.D. Williams, A. Mulindwa, A. Uyungrwoth, I. Raus, O. Mostovenko, T. Stepchenkova, A. Volokha, N. Primak, J. Kenny, A. Callaghan, M. Ahmad, S. Vergnano, M. Ross, F. Manyi, D. Nayagam, S. Hawkins, C. Ball, E. Hamlyn, C. Gilmour, S. Gilmour-White, S. Doshi, E. Fuller, A. Adebayo, K. Tupper, E. Nsirim, S. Welch, J. Daglish, L. Thrasyvoulou, E. Irvine, K. Gandhi, Y. Vaughn-Gordon, N. Sibanda

المصدر: EClinicalMedicine, Vol 60, Iss , Pp 102025- (2023)

مصطلحات موضوعية: HIV, Children, Adolescents, Randomised, Paediatrics, Dual therapy, Medicine (General), R5-920

الوصف: Summary: Background: Integrase inhibitor (INSTI) with boosted darunavir (DRV/r), a regimen with a high-resistance barrier, avoiding NRTI toxicities, might be a switching option in children living with HIV (CLWHIV). Methods: SMILE is a randomised non-inferiority trial evaluating safety and antiviral efficacy of once-daily INSTI + DRV/r vs. continuing on current standard-of-care (SOC) triple ART (2NRTI + boosted PI/NNRTI) in virologically-suppressed CLWHIV aged 6–18 years. The primary outcome is the proportion with confirmed HIV-RNA ≥50 copies/mL by week 48, estimated by Kaplan–Meier method. Non-inferiority margin was 10%. Registration number for SMILE are: ISRCTN11193709, NCT #: NCT02383108. Findings: Between 10th June 2016 and 30th August 2019, 318 participants were enrolled from Africa 53%, Europe 24%, Thailand 15% and Latin America 8%, 158 INSTI + DRV/r [153 Dolutegravir (DTG); 5 Elvitegravir (EVG)], 160 SOC. Median (range) age was 14.7 years (7.6–18.0); CD4 count 782 cells/mm3 (227–1647); 61% female. Median follow-up was 64.3 weeks with no loss to follow-up. By 48 weeks, 8 INSTI + DRV/r vs. 12 SOC had confirmed HIV-RNA ≥50 copies/mL; difference (INSTI + DRV/r-SOC) −2.5% (95% CI: −7.6, 2.5%), showing non-inferiority. No major PI or INSTI resistance mutations were observed. There were no differences in safety between arms. By week 48, difference (INSTI + DRV/r-SOC) in mean CD4 count change from baseline was −48.3 cells/mm3 (95% CI: −93.4, −3.2; p = 0.036). Difference (INSTI + DRV/r-SOC) in mean HDL change from baseline was −4.1 mg/dL (95% CI: −6.7, −1.4; p = 0.003). Weight and Body Mass Index (BMI) increased more in INSTI + DRV/r than SOC [difference: 1.97 kg (95% CI: 1.1, 2.9; p

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S258953702300202XTest; https://doaj.org/toc/2589-5370Test

الوصول الحر: https://doaj.org/article/d11bedec365049ddb8bbcee69219535fTest