دورية أكاديمية
Robust and specific secretory IgA against SARS-CoV-2 detected in human milk
| العنوان: | Robust and specific secretory IgA against SARS-CoV-2 detected in human milk |
|---|---|
| المؤلفون: | Fox, Alisa, Marino, Jessica, Amanat, Fatima, Krammer, Florian, Hahn-Holbrook, Jennifer, Zolla-Pazner, Susan, Powell, Rebecca L. |
| المصدر: | iScience |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Repositório Institucional da Universidade Federal de Lavras (RIUFLA) |
| مصطلحات موضوعية: | COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Immunoglobulin A (IgA), Human milk |
| الوصف: | The SARS-CoV-2 immune response in human milk has not yet been examined, though protecting infants and young children from COVID-19 is critical for limiting community transmission, and preventing serious illness and death. Here, milk samples from 8 COVID-19-recovered and 7 COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, while 80% exhibited significant IgA and secretory (s)Ab binding to the receptor binding domain (RBD). Additionally, 67% of samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality, and the potential for exploiting extracted milk sIgA for therapeutic use. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | FOX, A. et al. Robust and specific secretory IgA against SARS-CoV-2 detected in human milk. iScience, [S.l.], 2020. No prelo.; https://www.sciencedirect.com/science/article/pii/S2589004220309329Test; http://repositorio.ufla.br/jspui/handle/1/45343Test |
| الإتاحة: | http://repositorio.ufla.br/jspui/handle/1/45343Test https://www.sciencedirect.com/science/article/pii/S2589004220309329Test |
| حقوق: | restrictAccess |
| رقم الانضمام: | edsbas.68EB6B12 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |