المؤلفون: Wong, David M., Li, ngli Li, Jurado, Sabine, King, Ashleigh, Bamford, Rebecca, Wall, Meaghan, Walia, Mannu K., Kelly, Gemma L., Walkley, Carl R., Tarlinton, David M., Strasser, Andreas, Heierhorst, Jörg

الوصف: How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-B cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.

وصف الملف: application/pdf

العلاقة: https://acuresearchbank.acu.edu.au/item/874q6/the-transcription-factor-asciz-and-its-target-dynll1-are-essential-for-the-development-and-expansion-of-myc-driven-b-cell-lymphomaTest; https://acuresearchbank.acu.edu.au/download/c0bdcb37a09719b4da67a04a044d92eea8b9979c60fc675954345b743b72208a/3815560/OA_Wong_2016_The_transcription_of_factor_ASCIZ_and.pdfTest; https://doi.org/10.1016/j.celrep.2016.01.012Test; Wong, David M., Li, ngli Li, Jurado, Sabine, King, Ashleigh, Bamford, Rebecca, Wall, Meaghan, Walia, Mannu K., Kelly, Gemma L., Walkley, Carl R., Tarlinton, David M., Strasser, Andreas and Heierhorst, Jörg. (2016). The transcription factor ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma. Cell Reports. 14(6), pp. 1488 - 1499. https://doi.org/10.1016/j.celrep.2016.01.012Test

الإتاحة: https://doi.org/10.1016/j.celrep.2016.01.012Test
https://acuresearchbank.acu.edu.au/download/c0bdcb37a09719b4da67a04a044d92eea8b9979c60fc675954345b743b72208a/3815560/OA_Wong_2016_The_transcription_of_factor_ASCIZ_and.pdfTest

المؤلفون: Kelly, Gemma L., Strasser, Andreas

المصدر: Advances in Cancer Research ; page 39-96 ; ISSN 0065-230X ; ISBN 9780123855244

الإتاحة: https://doi.org/10.1016/b978-0-12-385524-4.00002-7Test