دورية أكاديمية
Association between ventricular repolarization parameters and cardiovascular death in patients of the SWISS-AF cohort
| العنوان: | Association between ventricular repolarization parameters and cardiovascular death in patients of the SWISS-AF cohort |
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| المؤلفون: | Rivolta M. W., Mainardi L. T., Laureanti R., Sassi R., Kuhne M., Rodondi N., Conte G., Moschovitis G., Schlageter V., Aeschbacher S., Conen D., Reichlin T., Roten L., Osswald S., Zuern C. S., Auricchio A., Corino V. D. A. |
| المساهمون: | M.W. Rivolta, L.T. Mainardi, R. Laureanti, R. Sassi, M. Kuhne, N. Rodondi, G. Conte, G. Moschoviti, V. Schlageter, S. Aeschbacher, D. Conen, T. Reichlin, L. Roten, S. Osswald, C.S. Zuern, A. Auricchio, V.D.A. Corino |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Atrial fibrillation, Mortality, QTc, V-index, Ventricular repolarization heterogeneity, Cohort Studie, Electrocardiography, Human, Prospective Studie, Risk Factor, Settore INF/01 - Informatica, Settore ING-INF/06 - Bioingegneria Elettronica e Informatica, Settore MED/11 - Malattie dell'Apparato Cardiovascolare |
| الوصف: | Background: The effect of the ventricular repolarization heterogeneity has not been systematically assessed in patients with atrial fibrillation (AF). Aim of this study is to assess ventricular repolarization heterogeneity as predictor of cardiovascular (CV) death and/or other CV events in patients with AF. Methods: From the multicenter prospective Swiss-AF (Swiss Atrial Fibrillation) Cohort Study, we enrolled 1711 patients who were in sinus rhythm (995) or AF (716). Resting ECG recordings of 5-min duration were obtained at baseline. Parameters assessing ventricular repolarization were computed (QTc, Tpeak-Tend, J-Tpeak and V-index). Results: During AF, the V-index was found repeatable (no differences when computed over the whole recording, on the first 2.5-min and on the last 2.5-min segments). During a mean follow-up time of 2.6 ± 1.0 years, 90 patients died for CV reasons. In bivariate Cox regression analysis (adjusted for age only), the V-index was associated with an increased risk of CV death, both in the subgroup of patients in sinus rhythm (SR) as well as those in AF. In multivariate analysis adjusted for clinical risk factors and medications, both prolonged QTc and V-index were independently associated with an increased risk of CV death (QTc: hazard ratio [HR] 2.78, 95% CI 1.79–4.32, p < 0.001; V-index: HR 1.73, 95% CI 1.12–2.69, p = 0.014). Conclusions: QTc and V-index, measured in a single 5-min ECG recording, were independent predictors of CV death in a cohort of patients with AF and might be a valuable tool for further risk stratification to guide patient management. Clinical Trial Identifier Swiss-AF study: NCT02105844 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35278571; info:eu-repo/semantics/altIdentifier/wos/WOS:000796372100011; volume:356; firstpage:53; lastpage:59; numberofpages:7; journal:INTERNATIONAL JOURNAL OF CARDIOLOGY; https://hdl.handle.net/2434/937488Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85126339314 |
| DOI: | 10.1016/j.ijcard.2022.03.009 |
| الإتاحة: | https://doi.org/10.1016/j.ijcard.2022.03.009Test https://hdl.handle.net/2434/937488Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.29C11C3B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijcard.2022.03.009 |
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