دورية أكاديمية
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer
| العنوان: | DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer |
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| المؤلفون: | George, Vazhappilly Cijo, Ansari, Shabbir Ahmed, Chelakkot, Vipin Shankar, Chelakkot, Ayshwarya Lakshmi, Chelakkot, Chaithanya, Menon, Varsha, Ramadan, Wafaa, Ethiraj, Kannatt Radhakrishnan, El-Awady, Raafat, Mantso, Theodora, Mitsiogianni, Melina, Panagiotidis, Mihalis, Dellaire, Graham, Vasantha Rupasinghe, H.P. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Northumbria University, Newcastle: Northumbria Research Link (NRL) |
| مصطلحات موضوعية: | C400 Genetics |
| الوصف: | DNA-dependent protein kinase (DNA-PK), a member of phosphatidylinositol-kinase family, is a key protein in mammalian DNA double-strand break (DSB) repair that helps to maintain genomic integrity. DNA-PK also plays a central role in immune cell development and protects telomerase during cellular aging. Epigenetic deregulation due to endogenous and exogenous factors may affect the normal function of DNA-PK, which in turn could impair DNA repair and contribute to genomic instability. Recent studies implicate a role for epigenetics in the regulation of DNA-PK expression in normal and cancer cells, which may impact cancer progression and metastasis as well as provide opportunities for treatment and use of DNA-PK as a novel cancer biomarker. In addition, several small molecules and biological agents have been recently identified that can inhibit DNA-PK function or expression, and thus hold promise for cancer treatments. This review discusses the impact of epigenetic alterations and the expression of DNA-PK in relation to the DNA repair mechanisms with a focus on its differential levels in normal and cancer cells. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://nrl.northumbria.ac.uk/id/eprint/36887/1/Mutation%20Research.pdfTest; George, Vazhappilly Cijo, Ansari, Shabbir Ahmed, Chelakkot, Vipin Shankar, Chelakkot, Ayshwarya Lakshmi, Chelakkot, Chaithanya, Menon, Varsha, Ramadan, Wafaa, Ethiraj, Kannatt Radhakrishnan, El-Awady, Raafat, Mantso, Theodora, Mitsiogianni, Melina, Panagiotidis, Mihalis, Dellaire, Graham and Vasantha Rupasinghe, H.P. (2019) DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. Mutation Research/Reviews in Mutation Research, 780. pp. 92-105. ISSN 1383-5742 |
| DOI: | 10.1016/j.mrrev.2018.06.001 |
| الإتاحة: | https://doi.org/10.1016/j.mrrev.2018.06.001Test https://nrl.northumbria.ac.uk/id/eprint/36887Test/ https://nrl.northumbria.ac.uk/id/eprint/36887/1/Mutation%20Research.pdfTest |
| حقوق: | cc_by_nc_nd_4_0 |
| رقم الانضمام: | edsbas.9936915 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.mrrev.2018.06.001 |
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