دورية أكاديمية
Protamine reversal of anticoagulation achieved with a low molecular weight heparin. The effects on eicosanoids, clotting and complement factors
| العنوان: | Protamine reversal of anticoagulation achieved with a low molecular weight heparin. The effects on eicosanoids, clotting and complement factors |
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| المؤلفون: | Lindblad, Bengt, Borgstrom, Anders, Wakefield, Thomas W., Whitehouse, Walter M. Jr., Stanley, James C. |
| المساهمون: | Division of Peripheral Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA |
| بيانات النشر: | Elsevier |
| سنة النشر: | 1987 |
| المجموعة: | University of Michigan: Deep Blue |
| مصطلحات موضوعية: | Internal Medicine and Specialties, Health Sciences |
| الوصف: | Hemodynamic and hematologic effects of protamine reversal of low molecular weight heparin (LMWH) anticoagulation with and without protamine pretreatment, as well as reversal of anticoagulation with unfractionated standard heparin (SH), were studied in canine subjects. Protamine reversal caused less severe thrombocytopenia in the two LMWH groups compared to SH animals, while neutropenia occurred equally in all groups. Cl-esterase inhibitor levels were minimally increased, whereas C3 levels and leucotriene levels were unaltered. TxB2 and 6-keto-PGF1[alpha] increased during protamine reversal of LMWH anticoagulation. TCT and APTT were affected less with LMWH than SH anticoagulation. Anti-Xa levels increased with anticoagulation in all animals, but protamine did not reverse the elevated anti-Xa levels in LMWH anticoagulated dogs to the same degree as occurred with SH anticoagulation. TCT, APTT and bleeding times were normalized by protamine in all animals. Protamine reversal of LMWH anticoagulation with or without protamine pretreatment did not reveal any clear differences in eicosanoids or complement factors compared to SH anticoagulation, although differences in anti-Xa activity clearly separated these two heparins. ; Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/26544/1/0000083.pdfTest |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 664938 bytes; 3118 bytes; application/pdf; text/plain |
| اللغة: | English |
| العلاقة: | Lindblad, Bengt, Borgstrom, Anders, Wakefield, Thomas W., Whitehouse, Jr., Walter M., Stanley, James C. (1987/10/01)."Protamine reversal of anticoagulation achieved with a low molecular weight heparin. The effects on eicosanoids, clotting and complement factors." Thrombosis Research 48(1): 31-40.; http://www.sciencedirect.com/science/article/B6T1C-4C2SFCP-26/2/d120579576bce1d7c71f8f6ed758ef2aTest; http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2827339&dopt=citationTest; https://hdl.handle.net/2027.42/26544Test; 2827339; http://dx.doi.org/10.1016/0049-3848Test(87)90343-4; Thrombosis Research |
| DOI: | 10.1016/0049-3848(87)90343-4 |
| الإتاحة: | https://doi.org/10.1016/0049-3848Test(87)90343-4 https://hdl.handle.net/2027.42/26544Test http://www.sciencedirect.com/science/article/B6T1C-4C2SFCP-26/2/d120579576bce1d7c71f8f6ed758ef2aTest http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2827339&dopt=citationTest |
| حقوق: | IndexNoFollow |
| رقم الانضمام: | edsbas.E72E369A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/0049-3848(87)90343-4 |
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