دورية أكاديمية
The effect of a duodenal-jejunal bypass liner on lipid profile and blood concentrations of long chain polyunsaturated fatty acids
| العنوان: | The effect of a duodenal-jejunal bypass liner on lipid profile and blood concentrations of long chain polyunsaturated fatty acids |
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| المؤلفون: | Glaysher, M, Ward, J, Aldhwayan, M, Ruban, A, Prechtl, CG, Fisk, HL, Chhina, N, Al-Najim, W, Smith, C, Klimowska-Nassar, N, Johnson, N, Falaschetti, E, Goldstone, AP, Miras, AD, Byrne, JP, Calder, PC, Teare, J |
| المساهمون: | Medical Research Council (MRC), National Institute for Health Research, Fractyl Laboratories, Inc., The Jon Moulton Charity Trust, Imperial College Healthcare NHS Trust |
| المصدر: | 2354 ; 2343 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, Endobarrier, Duodenal-jejunal bypass liner, Endoscopic bariatric therapies, Obesity, Lipids, Polyunsaturated fatty acids, LIFE-STYLE INTERVENTION, BARIATRIC SURGERY, WEIGHT-LOSS, GLYCEMIC CONTROL, OBESE-PATIENTS, METABOLIC THERAPIES, TYPE-2, REDUCTION, IMPROVEMENT, OUTCOMES, Surgery, 1111 Nutrition and Dietetics |
| الوصف: | Background & aims Duodenal-jejunal bypass liners (DJBLs) prevent absorption in the proximal small intestine, the site of fatty acid absorption. We sought to investigate the effects of a DJBL on blood concentrations of essential fatty acids (EFAs) and bioactive polyunsaturated fatty acids (PUFAs). Methods Sub-study of a multicentre, randomised, controlled trial with two treatment groups. Patients aged 18–65 years with type-2 diabetes mellitus and body mass index 30–50 kg/m2 were randomised to receive a DJBL for 12 months or best medical therapy, diet and exercise. Whole plasma PUFA concentrations were determined at baseline, 10 days, 6 and 11.5 months; data were available for n = 70 patients per group. Results Weight loss was significantly greater in the DJBL group compared to controls after 11.5 months: total body weight loss 11.3 ± 5.3% versus 6.0 ± 5.7% (mean difference [95% CI] = 5.27% [3.75, 6.80], p < 0.001). Absolute concentrations of both EFAs, linoleic acid and α-linolenic acid, and their bioactive derivatives, arachidonic acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, were significantly lower in the DJBL group than in the control group at 6 and 11.5 months follow-up. Total serum cholesterol, LDL-cholesterol and HDL-cholesterol were also significantly lower in the DJBL group. Conclusion One year of DJBL therapy is associated with superior weight loss and greater reductions in total serum cholesterol and LDL-cholesterol, but also depletion of EFAs and their longer chain derivatives. DJBL therapy may need to be offset by maintaining an adequate dietary intake of PUFAs or by supplementation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0261-5614 |
| العلاقة: | Clinical Nutrition; http://hdl.handle.net/10044/1/84861Test; G0902002; 12/10/04; 4581; Prof Alex Miras; FR717; FR420; WREE_P84939 |
| DOI: | 10.1016/j.clnu.2020.10.026 |
| الإتاحة: | https://doi.org/10.1016/j.clnu.2020.10.026Test http://hdl.handle.net/10044/1/84861Test |
| حقوق: | © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0Test/) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.89CC5C48 |
| قاعدة البيانات: | BASE |
| تدمد: | 02615614 |
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| DOI: | 10.1016/j.clnu.2020.10.026 |