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Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study

التفاصيل البيبلوغرافية
العنوان: Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study
المؤلفون: Loftus, Christine T, Szpiro, Adam A, Workman, Tomomi, Wallace, Erin R, Hazlehurst, Marnie F, Day, Drew B, Ni, Yu, Carroll, Kecia N, Adgent, Margaret A, Moore, Paul E, Barrett, Emily S, Nguyen, Ruby HN, Kannan, Kurunthachalam, Robinson, Morgan, Masterson, Erin E, Tylavsky, Frances A, Bush, Nicole R, LeWinn, Kaja Z, Sathyanarayana, Sheela, Karr, Catherine J
المصدر: Environ Int
بيانات النشر: Elsevier
eScholarship, University of California
سنة النشر: 2022
مصطلحات موضوعية: Article, demo, envir
الوصف: BACKGROUND: Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) may increase risk of pediatric asthma, but existing human studies are limited. OBJECTIVES: We estimated associations between gestational PAHs and pediatric asthma in a diverse US sample and evaluated effect modification by child sex, maternal asthma, and prenatal vitamin D status. METHODS: We pooled two prospective pregnancy cohorts in the ECHO PATHWAYS Consortium, CANDLE and TIDES, for an analytic sample of N=1296 mother-child dyads. Mono-hydroxylated PAH metabolites (OH-PAHs) were measured in mid-pregnancy urine. Mothers completed the International Study on Allergies and Asthma in Childhood survey at child age 4–6 years. Poisson regression with robust standard errors was used to estimate relative risk of current wheeze, current asthma, ever asthma, and strict asthma associated with each metabolite, adjusted for potential confounders. We used interaction models to assess effect modification. We explored associations between OH-PAH mixtures and outcomes using logistic regression weighted quantile sum augmented by a permutation test to control Type 1 errors. RESULTS: The sociodemographically diverse sample spanned five cities. Mean (SD) child age at assessment was 4.4 (0.4) years. While there was little evidence that either individual OH-PAHs or mixtures were associated with outcomes, we observed effect modification by child sex for most pairs of OH-PAHs and outcomes, with adverse associations specific to females. For example, a 2-fold increase in 2-hydroxy-phenanthrene was associated with current asthma in females but not males (RR(female) = 1.29 [95% CI: 1.09, 1.52], RR(male) = 0.95 [95% CI: 0.79, 1.13]; p(interaction) = 0.004). There was no consistent evidence of modification by vitamin D status or maternal asthma. DISCUSSION: This analysis, the largest cohort study of gestational PAH exposure and childhood asthma to date, suggests adverse associations for females only. These preliminary findings are consistent with hypothesized endocrine .
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0160-4120
العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810359Test/
DOI: 10.1016/j.envint.2022.107494
الإتاحة: https://doi.org/10.1016/j.envint.2022.107494Test
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810359Test/
حقوق: undefined
رقم الانضمام: edsbas.4AC12B44
قاعدة البيانات: BASE
الوصف
تدمد:01604120
DOI:10.1016/j.envint.2022.107494