دورية أكاديمية
The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study
| العنوان: | The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study |
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| المؤلفون: | Akyildiz, Utku Ogan, Tezer, F. Irsel, Koc, Guray, Ismailogullari, Sevda, Demir, Aylin Bican, Ak, Aysin Kisabay, Senel, Gulcin Benbir |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Narcolepsy, REM sleep, REM sleep Without atonia, Rapid eye movement index, Periodic Leg Movements, Latency Test, Eye-Movements, Cataplexy, Mslt, Hypersomnia, Type-1, Wakefulness, Predictors, Diagnosis |
| الوصف: | Introduction: Narcolepsy type 1 (NT1) is caused by hypocretin deficiency, the pathophysiology of narcolepsy type 2 (NT2) has not been delineated. Except for the hypocretin deficiency and cataplexy, all clinical and laboratory features used in the diagnosis of NT2 are identical to those used for NT1. The aim of this study was to assess the rapid eye movement (REM) sleep-related characteristics in the patients with narcolepsy; the characteristics of REM sleep in polysomnography (PSG) and multiple sleep latency test (MSLT) recordings, the quantification of REM sleep without atonia (RSWA) and atonia index, and the analysis of rapid eye movements (REMs) during REM sleep. Materials and methods: This study was planned by the Sleep Medicine Study Group of the Turkish Neurology Society, and conducted in 11 centers in eight cities in Turkey. The analysis of RSWA was analyzed by reviewing all REM sleep periods on nocturnal PSG and MSLT recordings per standard criteria. The total duration of the increased muscle tone during REM sleep in the chin and bilateral leg electromyography (EMG) recordings was calculated as RSWA index. The REMs index was also investigated the relation to the RSWA. Results: A total of 274 patients were involved; 147 patients (53.6%) were males and 127 patients (46.4%) were females; the mean age was 29.1 +/- 12.0 years. The diagnosis of NT1 was made in 166 patients (60.6%), and 108 patients (39.4%) were diagnosed as having NT2. The mean Epworth sleepiness scale score was significantly higher in patients with NT1 than the patients with NT2 (P = 0.001). The diagnosis of REM sleep behavior disorder (RBD) was made in 19.3% of the patients with NT1 versus in 2.8% of the patients with NT2 (P < 0.001). The percentage of SOREMP in PSG recordings was significantly higher in patients with NT1 (37.1%) than those with NT2 (18.9%, P = 0.001). MSLT showed that the mean sleep latency was shorter in patients with NT1 compared to those with NT2 (P < 0.001). The total duration of REMs on electrooculography ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-831312-8 0-00-831312-1 |
| تدمد: | 1389-9457 1878-5506 |
| العلاقة: | Sleep Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1016/j.sleep.2022.03.025Test; https://hdl.handle.net/20.500.12831/7841Test; 94; 17; 25; WOS:000831312100003; 2-s2.0-85128253874 |
| DOI: | 10.1016/j.sleep.2022.03.025 |
| الإتاحة: | https://doi.org/10.1016/j.sleep.2022.03.025Test https://doi.org/20.500.12831/7841Test https://hdl.handle.net/20.500.12831/7841Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.79FD67C8 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780008313128 0008313121 |
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| تدمد: | 13899457 18785506 |
| DOI: | 10.1016/j.sleep.2022.03.025 |