دورية أكاديمية
Prevalence of Microvascular and Macrovascular Disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study Cohort
| العنوان: | Prevalence of Microvascular and Macrovascular Disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study Cohort |
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| المؤلفون: | Mather, Kieren J., Bebu, Ionut, Baker, Chelsea, Cohen, Robert M., Crandall, Jill P., DeSouza, Cyrus, Green, Jennifer B., Kirkman, M. Sue, Krause-Steinrauf, Heidi, Larkin, Mary, Pettus, Jeremy, Seaquist, Elizabeth R., Soliman, Elsayed Z., Schroeder, Emily B., Wexler, Deborah J., Pop-Busui, Rodica |
| المساهمون: | Medicine, School of Medicine |
| المصدر: | PMC |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: | Diabetes, Complications, Prevalence, Treatment, Comparative effectiveness, Pragmatic |
| الوصف: | Aims: The Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) trial is a randomized clinical trial comparing glycemic effects of four diabetes medications added to metformin in type 2 diabetes (T2D). Microvascular and macrovascular diseases are secondary outcomes. We evaluated the prevalence and risk factor relationships for microvascular and macrovascular complications in the GRADE cohort at study entry. Methods: Complication prevalence and risk factors were analyzed based on data from screening in all consenting participants meeting GRADE eligibility. Logistic regression and Z-statistics were used to assess risk factor relationships with complications. Results: We enrolled 5047 T2D participants [mean age 57 years; 36% female; mean known T2D duration 4 years (all < 10 years); mean HbA1c 8.0% (∼64 mmol/mol) at screening]. Urinary albumin/creatinine ratio (ACR) ≥ 30 mg/gram was present in 15.9% participants; peripheral neuropathy (by Michigan Neuropathy Screening Instrument) in 21.5%; cardiovascular autonomic neuropathy by electrocardiography-derived indices in 9.7%; self-reported retinopathy in 1.0%. Myocardial infarction ascertained by self-report or electrocardiogram was present in 7.3%, and self-reported history of stroke in 2.0%. Conclusions: In the GRADE cohort with < 10 years of T2D and a mean HbA1c of 8.0%, diabetes complications were present in a substantial fraction of participants, more so than might otherwise have been expected. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Diabetes Research and Clinical Practice; Mather KJ, Bebu I, Baker C, et al. Prevalence of microvascular and macrovascular disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study cohort. Diabetes Res Clin Pract. 2020;165:108235. doi:10.1016/j.diabres.2020.108235; https://hdl.handle.net/1805/31259Test |
| الإتاحة: | https://doi.org/10.1016/j.diabres.2020.108235Test https://hdl.handle.net/1805/31259Test |
| حقوق: | Publisher Policy |
| رقم الانضمام: | edsbas.F2239330 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |