Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors
| العنوان: | Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors |
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| المؤلفون: | Noriaki Koshikawa, Junzo Kamei, Alexander R. Cools, Hiroko Ikeda |
| المصدر: | Journal of Pharmacological Sciences, Vol 120, Iss 3, Pp 152-164 (2012) Journal of Pharmacological Sciences, 120, 152-64 Journal of Pharmacological Sciences, 120, 3, pp. 152-64 |
| بيانات النشر: | Elsevier, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | DCN MP - Plasticity and memory, Dopamine, Nerve Tissue Proteins, D1-like receptor, Nucleus accumbens, Nucleus Accumbens, medicine, Animals, Receptor, Long-term depression, Neurons, Pharmacology, Behavior, Animal, Chemistry, Dopaminergic, lcsh:RM1-950, Rats, Receptors, Neurotransmitter, lcsh:Therapeutics. Pharmacology, Dopamine receptor, D2-like receptor, Molecular Medicine, Obsessive Behavior, Neuroscience, medicine.drug |
| الوصف: | Contains fulltext : 108879.pdf (Publisher’s version ) (Open Access) Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson's disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they interact with dopaminergic function: this is because modifying accumbal dopamine has far-reaching consequences for the treatment of diseases in which accumbal dopamine is involved. This review provides a summary of these interactions, and our current knowledge about them are as follows: A) AMPA receptors are required for dopamine-dependent behavior and vice versa; NMDA receptors modulate the activity at the level of AMPA and/or dopamine D(1) receptors. B) GABA(A), but not GABA(B), receptors inhibit dopamine-dependent behavior. C) Nicotinic receptors are required for dopamine-dependent behavior, whereas muscarinic receptors inhibit dopamine-dependent behavior. D) alpha-Adrenoceptors inhibit dopamine-dependent behavior in contrast to beta-adrenoceptors, which potentiate this behavior. E) mu- and delta(2)-opioid receptors elicit behavior that requires an intact dopaminergic function and delta(2)-opioid receptors modulate dopamine-dependent behavior. F) Orexin 2 receptors play an important, modifying role in dopamine-dependent behavior. G) Somatostatin receptors potentiate dopamine-dependent behavior. It is suggested that modulation of the above-mentioned non-dopaminergic receptors provide new tools to control physiological functions as well as diseases mediated by accumbal dopamine. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1347-8613 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71407a6828f875a9dd64e46833065347Test http://www.sciencedirect.com/science/article/pii/S134786131930430XTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....71407a6828f875a9dd64e46833065347 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13478613 |
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