المؤلفون: Julian Zipfel, Cristina Kohlmann-Dell’Acqua, Susan Noell, Leonidas Trakolis

المصدر: World Neurosurgery: X, Vol 22, Iss , Pp 100293- (2024)

مصطلحات موضوعية: Normal pressure hydrocephalus, Shunt, Overdrainage, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective: Complication rate of shunting for normal pressure hydrocephalus (NPH) has significantly improved over the last decades. Especially the use of overdrainage protection has reduced the incidence of subdural hematoma and collections. However, gravitational valves were associated with other complications of shunt dysfunction. We present our 17 years of experience with patients with normal pressure hydrocephalus who changed from a differential pressure valve to a gravitational valve system. Methods: We retrospectively identified all patients with the diagnosis of normal pressure hydrocephalus, in whom primary shunt implantation was performed between 2004 and 2020. Shunt implantation was performed as per our internal standard. Review of imaging, charts and patient reports was performed. Results: In total, 409 patients were included in the analysis. Mean age was 73.0 ± 7.1years. Between 2004 and 2010, predominantly Hakim valves (n = 100, 24.4%) were implanted, whilst from 2009 until 2020, proGAV valves (n = 296, 72.4%) were used. Mean follow-up was 8.9 ± 4.5 years. Initial subjective improvement of symptoms was reported in 69.9%, whilst this number decreased at the last follow-up to 29.8%. No significant differences were observed between the valves in the frequency of surgery for subdural hematoma. Shunt assistant implantation was performed in 17% of patients with Hakim valve, in 9.5% of patients with proGAV, a shunt assistant was added. Shunt obstruction was significantly higher in proGAV valves (p

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2590139724000243Test; https://doaj.org/toc/2590-1397Test

الوصول الحر: https://doaj.org/article/74de198877764d29aafd978f14ce7507Test

المؤلفون: Jacob T. Hanson, Luke T. Sabal, James N. Jean, Alec Jonason, Reid Johnson, Thomas Lisko, Yeng Moua, Robert A. McGovern

المصدر: World Neurosurgery: X, Vol 22, Iss , Pp 100299- (2024)

مصطلحات موضوعية: Normal pressure hydrocephalus, Postural instability, Kinematics, Diagnosis, Parkinson's disease, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective: Patients with normal pressure hydrocephalus (NPH) and Parkinson's Disease (PD) can clinically appear quite similar at baseline evaluation. We sought to investigate the use of kinematic assessment of postural instability (PI) using inertial measurement units (IMUs) as a mechanism of differentiation between the two disease processes. Methods: 20 patients with NPH, 55 patients with PD, and 56 age-matched, healthy controls underwent quantitative pull test examinations while wearing IMUs at baseline. Center of mass and foot position data were used to compare velocity and acceleration profiles, pull test step length, and reaction times between groups and as a function of Unified Parkinson's disease Rating Scale Pull Test (UPDRSPT) score. Results: Overall, the reactive postural response of NPH patients was characterized by slower reaction times and smaller steps compared to both PD patients and healthy controls. However, when patients were grouped by UPDRSPT scores, no reliable objective difference between groups was detected. Conclusion: At their initial evaluation, very few NPH patients demonstrate “normal” or “mild” PI as they appear to be older upon presentation compared to PD patients. As a result, kinematic assessment utilizing IMUs may not be helpful for differentiating between NPH and PD as a function of UPDRSPT score, but rather as a more fine-tuned method to define disease progression. We emphasize the need for further evaluation of incorporating objective kinematic data collection as a way to evaluate PI and improve patient outcomes.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2590139724000309Test; https://doaj.org/toc/2590-1397Test

الوصول الحر: https://doaj.org/article/e8506ece781440d0bc96d216dc50754cTest

المؤلفون: Meryem Lamjoun, MD, Adil Jelti, MD, Fatima Elghazouani, PhD, Mohamed Barrimi, PhD

المصدر: Radiology Case Reports, Vol 18, Iss 7, Pp 2397-2400 (2023)

مصطلحات موضوعية: Idiopathic chronic hydrocephalus, Normal pressure hydrocephalus, Encephalic MRI, Psychiatric symptoms, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Normal pressure hydrocephalus typically presents with a clinical triad of progressively worsening symptoms, including gait disturbance, urinary incontinence, and cognitive deficits. Occasionally, it may also manifest with significant psychiatric symptoms, which can delay early diagnosis and treatment. We present a rare case of chronic hydrocephalus in a 54-year-old patient who initially presented with symptoms of mania, which led to a delay in diagnosis and treatment. Our case highlights the importance of considering organic causes for psychiatric symptoms, especially in older patients. Early diagnosis and treatment of conditions such as hydrocephalus can prevent delays and improve patient outcomes.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S193004332300211XTest; https://doaj.org/toc/1930-0433Test

الوصول الحر: https://doaj.org/article/c285f65928af404982fdabf4f5b996b1Test

المؤلفون: Keru Huang, Jiaojiang He, Liangxue Zhou

المصدر: Asian Journal of Surgery, Vol 47, Iss 3, Pp 1705-1706 (2024)

مصطلحات موضوعية: Normal pressure hydrocephalus, Colon perforation, Shunt, Surgery, RD1-811

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1015958423020092Test; https://doaj.org/toc/1015-9584Test

الوصول الحر: https://doaj.org/article/a9e7d80c4ce6442a894920f0500b6662Test

المؤلفون: Jeremi Chabros, Michal M. Placek, Ka Hing Chu, Erta Beqiri, Peter J. Hutchinson, Zofia Czosnyka, Marek Czosnyka, Alexis Joannides, Peter Smielewski

المصدر: Brain and Spine, Vol 4, Iss , Pp 102837- (2024)

مصطلحات موضوعية: Intracranial pressure, Brain physics, Normal pressure hydrocephalus, Bayesian inference, Cerebrospinal fluid dynamics, Infusion studies, Neurology. Diseases of the nervous system, RC346-429

الوصف: Introduction: Cerebrospinal fluid (CSF) infusion test analysis allows recognizing and appropriately evaluating CSF dynamics in the context of normal pressure hydrocephalus (NPH), which is crucial for effective diagnosis and treatment. However, existing methodology possesses drawbacks that may compromise the precision and interpretation of CSF dynamics parameters. Research question: This study aims to circumvent these constraints by introducing an innovative analysis method grounded in Bayesian inference. Material and methods: A single-centre retrospective cohort study was conducted on 858 patients who underwent a computerized CSF infusion test between 2004 and 2020. We developed a Bayesian framework-based method for parameter estimation and compared the results to the current, gradient descent-based approach. We evaluated the accuracy and reliability of both methods by analysing erroneous prediction rates and curve fitting errors. Results: The Bayesian method surpasses the gradient descent approach, reflected in reduced inaccurate prediction rates and an improved goodness of model fit. On whole cohort level both techniques produced comparable results. However, the Bayesian method holds an added advantage by providing uncertainty intervals for each parameter. Sensitivity analysis revealed significance of the CSF production rate parameter and its interplay with other variables. The resistance to CSF outflow demonstrated excellent robustness. Discussion and conclusion: The proposed Bayesian approach offers a promising solution for improving robustness of CSF dynamics assessment in NPH, based on CSF infusion tests. Additional provision of the uncertainty measure for each diagnostic metric may perhaps help to explain occasional poor diagnostic performance of the test, offering a robust framework for improved understanding and management of NPH.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2772529424000936Test; https://doaj.org/toc/2772-5294Test

الوصول الحر: https://doaj.org/article/e6544edef8ad45879f8976dc3f06635dTest

المؤلفون: Luyao Ma, Wencai Wang, Yongqiang Zhao, Menghao Liu, Wei Ye, Xianfeng Li

المصدر: Heliyon, Vol 10, Iss 1, Pp e23940- (2024)

مصطلحات موضوعية: Normal pressure hydrocephalus, Leucine-rich α-2 glycoprotein, Signaling pathway, Biomarkers, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: Normal pressure hydrocephalus (NPH) is a prevalent type of hydrocephalus, including secondary normal pressure hydrocephalus (SNPH) and idiopathic normal pressure hydrocephalus (INPH). However, its clinical diagnosis and pathological mechanism are still unclear. Leucine-rich α-2 glycoprotein (LRG) is involved in various human diseases, including cancer, diabetes, cardiovascular disease, and nervous system diseases. Now the physiological mechanism of LRG is still being explored. According to the current research results on LRG, we found that the agency of LRG has much to do with the known pathological process of NPH. This review focuses on analyzing the LRG signaling pathways and the pathological mechanism of NPH. According to the collected literature evidence, we speculated that LRG probably be involved in the pathological process of NPH. Finally, based on the mechanism of LRG and NPH, we also summarized the evidence of molecular targeted therapies for future research and clinical application.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844023111480Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/4716a4052db04271973a10a910cc91c7Test

المؤلفون: Derya Kaya, Ahmet Turan Isik

المصدر: Biomarkers in Neuropsychiatry, Vol 9, Iss , Pp 100071- (2023)

مصطلحات موضوعية: Normal pressure hydrocephalus, Inflammation, Neurofilament, Astroglia, Amyloid, Tau, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible disease characterized by gait disturbance, a frontal-subcortical pattern of cognitive impairment, and urinary incontinence with disproportionately enlarged ventricles. Its prevalence rises with aging. Patients with iNPH are treated with shunt placement, and predicting the surgical outcome is not always easy. Cerebrospinal fluid (CSF) has inevitably been an attractive matrix for biomarker identification in both the diagnosis and treatment of iNPH and the disease may have individual CSF composition changes. Additionally, in order to detect iNPH earlier, implement treatment faster, and have better therapeutic effects, the incorporation of CSF biomarkers in the diagnostic and treatment process is essential. In this review, CSF biomarkers of Alzheimer’s disease pathology, axonal damage, neuronal damage, astroglial dysfunction, myelin damage, inflammation, and extracellular matrix protein remodeling have been evaluated and tried to emphasize those of which have highly consistent findings in the studies. CSF samples collected only at a single time point may not be sufficient to identify a promising marker in such a dynamic and used to be a common comorbid condition to other neurodegenerative diseases. These confounders demonstrate the limitations of using solely biomarkers to diagnose the disease and to foresee the outcome of the shunt surgery. Therefore, CSF samples collected antemortem at different time points and biopsy-confirmed iNPH patients with and without other neurodegenerative diseases would fill the gaps in identifying a valid biomarker. Longitudinal observations of shunt responders and non-responders in multicenter with well-defined cohorts are also needed to understand iNPH-specific markers. Finally, biomarkers of a bioinformatic approach that includes micro-RNAs, extracellular vesicles, metabolomics, the microbiome, or else are warranted to identify novel and useful diagnostic and prognostic biomarker tools in iNPH.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666144623000114Test; https://doaj.org/toc/2666-1446Test

الوصول الحر: https://doaj.org/article/18ed58ea8e13492c9ec00b58a6f33019Test

المؤلفون: Hongen Bao, Fuming Tian, Hao Li, Changwu Dou

المصدر: Asian Journal of Surgery, Vol 46, Iss 5, Pp 2186-2188 (2023)

مصطلحات موضوعية: Spinal cord, Central nervous system, Normal pressure hydrocephalus, Cervical spondylotic myelopathy, Surgery, RD1-811

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1015958422016499Test; https://doaj.org/toc/1015-9584Test

الوصول الحر: https://doaj.org/article/04968234c9ab4c92a3e9f17a0c2ff9edTest

المؤلفون: Jasmine Liu-Zarzuela, Imran Hasnuddin, Mariam Mufti

المصدر: Brain Disorders, Vol 10, Iss , Pp 100073- (2023)

مصطلحات موضوعية: Flea-borne typhus, Dementia, Geriatric, Normal pressure hydrocephalus, Neurology. Diseases of the nervous system, RC346-429

الوصف: We report an inpatient case of flea-borne typhus (FBT) and normal pressure hydrocephalus in a 75-year-old male patient with a prior diagnosis of mixed Alzheimer and vascular dementia, who presented with acute onset of altered mental status, behavioral changes, Parkinsonism symptoms, and abnormal physical exam findings. Throughout his 11 day hospitalization, the patient demonstrated mixed hyperactive/hypoactive delirium in addition to his baseline dementia, resulting in a complex and unique presentation of FBT in a geriatric patient. The patient was treated with doxycycline, and his physical and cognitive symptoms improved over the course of his hospitalization.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666459323000100Test; https://doaj.org/toc/2666-4593Test

الوصول الحر: https://doaj.org/article/a5859d31a9cb4e268ddb68c148808168Test

المؤلفون: Zaksaite, Tara, Loveday, Catherine, Edginton, Trudi, Spiers, Hugo J., Smith, Alastair D.

مصطلحات موضوعية: Hydrocephalus, Spina bifida, Neuropsychology, Cognition, Normal pressure hydrocephalus

الوصف: Hydrocephalus is a common neurological condition, the hallmark feature of which is an excess in production, or accumulation, of cerebrospinal fluid in the ventricles. Although it is associated with diffuse damage to paraventricular brain areas, patients are broadly typified by a particular pattern of cognitive impairments that include deficits in working memory, attention, and spatial abilities. There have, however, been relatively few neuropsychological accounts of the condition. Moreover, theories of the relationship between aetiology and impairment appear to have emerged in isolation of each other, and proffer fundamentally different accounts. In this primer, we aim to provide a comprehensive and contemporary overview of hydrocephalus for the neuropsychologist, covering cognitive sequelae and theoretical interpretations of their origins. We review clinical and neuropsychological assays of cognitive profiles, along with the few studies that have addressed more integrative behaviours. In particular, we explore the distinction between congenital or early-onset hydrocephalus with a normal-pressure variant that can be acquired later in life. The relationship between these two populations is a singularly interesting one in neuropsychology since it can allow for the examination of typical and atypical developmental trajectories, and their interaction with chronic and acute impairment, within the same broad neurological condition. We reflect on the ramifications of this for our subject and suggest avenues for future research. [Abstract copyright: Copyright © 2023 The Authors. Published by Elsevier Ltd. All rights reserved.]

وصف الملف: application/pdf

العلاقة: https://westminsterresearch.westminster.ac.uk/download/8847fe15b6b23ed72ff384ea5ca7c4b96ca24ddb0e27934125258a66c1f36d1e/1390625/1-s2.0-S0010945223000102-main.pdfTest; https://doi.org/10.1016/j.cortex.2023.01.001Test; Zaksaite, Tara, Loveday, Catherine, Edginton, Trudi, Spiers, Hugo J. and Smith, Alastair D. 2023. Hydrocephalus: A neuropsychological and theoretical primer. Cortex. 160, pp. 67-99. https://doi.org/10.1016/j.cortex.2023.01.001Test

الإتاحة: https://doi.org/10.1016/j.cortex.2023.01.001Test
https://westminsterresearch.westminster.ac.uk/item/w1v77Test/hydrocephalus-a-neuropsychological-and-theoretical-primer
https://westminsterresearch.westminster.ac.uk/download/8847fe15b6b23ed72ff384ea5ca7c4b96ca24ddb0e27934125258a66c1f36d1e/1390625/1-s2.0-S0010945223000102-main.pdfTest