The combined effect of amyloid-β and tau biomarkers on brain atrophy in dementia with Lewy bodies
| العنوان: | The combined effect of amyloid-β and tau biomarkers on brain atrophy in dementia with Lewy bodies |
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| المؤلفون: | Zuzana Nedelska, Lena Cavallin, Frédéric Blanc, Dag Aarsland, Alessandro Padovani, Daniel Ferreira, Milica G. Kramberger, Andrea Pilotto, Mercè Boada, Carla Abdelnour, Ketil Oppedal, Eric Westman, Olivier Bousiges, Lars-Olof Wahlund, Jakub Hort, Jaime Kulisevsky, Laura Bonanni, Javier Pagonabarraga |
| المصدر: | NeuroImage: Clinical, Vol 27, Iss, Pp 102333-(2020) NeuroImage : Clinical Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona NeuroImage: Clinical |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Male, Disease, lcsh:RC346-429, 0302 clinical medicine, Alzheimer disease, Atrophy, Biomarkers, Lewy body disease, Neuroimaging, 05 social sciences, Neurodegeneration, Brain, Regular Article, Neurology, demens med Lewy-legemer, Cohort, lcsh:R858-859.7, Alzheimer's disease, medicine.medical_specialty, Cognitive Neuroscience, tau Proteins, lcsh:Computer applications to medicine. Medical informatics, behavioral disciplines and activities, 050105 experimental psychology, 03 medical and health sciences, Internal medicine, mental disorders, medicine, Humans, demens, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, biomarkører, lcsh:Neurology. Diseases of the nervous system, Aged, Amyloid beta-Peptides, Dementia with Lewy bodies, business.industry, Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 [VDP], medicine.disease, Peptide Fragments, nervous system diseases, nevrologi, nervous system, Neurology (clinical), Differential diagnosis, business, 030217 neurology & neurosurgery |
| الوصف: | Highlights • CSF Amyloid- β is related to medial temporal and posterior brain atrophy in Lewy body dementia. • CSF p-Tau is associated with posterior brain atrophy in Lewy body dementia. • CSF AD-related biomarkers are not related to atrophy in the frontal lobes. Background Alzheimer’s disease (AD)-related pathology is frequently found in patients with dementia with Lewy bodies (DLB). However, it is unknown how amyloid-β and tau-related pathologies influence neurodegeneration in DLB. Understanding the mechanisms underlying brain atrophy in DLB can improve our knowledge about disease progression, differential diagnosis, drug development and testing of anti-amyloid and anti-tau therapies in DLB. Objectives We aimed at investigating the combined effect of CSF amyloid-β42, phosphorylated tau and total tau on regional brain atrophy in DLB in the European DLB (E-DLB) cohort. Methods 86 probable DLB patients from the E-DLB cohort with CSF and MRI data were included. Random forest was used to analyze the association of CSF biomarkers (predictors) with visual rating scales for medial temporal lobe atrophy (MTA), posterior atrophy (PA) and global cortical atrophy scale-frontal subscale (GCA-F) (outcomes), including age, sex, education and disease duration as extra predictors. Results DLB patients with abnormal MTA scores had abnormal CSF Aβ42, shorter disease duration and older age. DLB patients with abnormal PA scores had abnormal levels of CSF Aβ42 and p-tau, older age, lower education and shorter disease duration. Abnormal GCA-F scores were associated with lower education, male sex, and older age, but not with any AD-related CSF biomarker. Conclusions This study shows preliminary data on the potential combined effect of amyloid-β and tau-related pathologies on the integrity of posterior brain cortices in DLB patients, whereas only amyloid-β seems to be related to MTA. Future availability of α-synuclein biomarkers will help us to understand the effect of α-synuclein and AD-related pathologies on brain integrity in DLB. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2213-1582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd54a5b9de6233453e21b5f37f2ae0eTest http://www.sciencedirect.com/science/article/pii/S2213158220301704Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8dd54a5b9de6233453e21b5f37f2ae0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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