دورية أكاديمية
American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma.
| العنوان: | American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma. |
|---|---|
| المؤلفون: | Giralt, Sergio, Garderet, Laurent, Durie, Brian, Cook, Gordon, Gahrton, Gosta, Bruno, Benedetto, Hari, Paremesweran, Lokhorst, Henk, McCarthy, Phillip, Krishnan, Amrita, Sonneveld, Pieter, Goldschmidt, Harmut, Jagannath, Sundar, Barlogie, Bart, Mateos, Maria, Gimsing, Peter, Sezer, Orhan, Mikhael, Joseph, Lu, Jin, Dimopoulos, Meletios, Mazumder, Amitabha, Palumbo, Antonio, Abonour, Rafat, Anderson, Kenneth, Attal, Michel, Blade, Joan, Bird, Jenny, Cavo, Michele, Comenzo, Raymond, de la Rubia, Javier, Einsele, Hermann, Garcia-Sanz, Ramon, Hillengass, Jens, Holstein, Sarah, Johnsen, Han, Joshua, Douglas, Koehne, Guenther, Kumar, Shaji, Kyle, Robert, Leleu, Xavier, Lonial, Sagar, Ludwig, Heinz, Nahi, Hareth, Nooka, Anil, Orlowski, Robert, Rajkumar, Vincent, Reiman, Anthony, Richardson, Paul, Rivas, Eloisa, San Miguel, Jesus, Turesson, Ingemar, Usmani, Saad, Vesole, David, Bensinger, William, Qazilbash, Muzaffer, Efebera, Yvonne, Mohty, Mohamed, Gasparreto, Christina, Gajewski, James, LeMaistre, Charles F, Bredeson, Chris, Moreau, Phillipe, Pasquini, Marcelo, Kroeger, Nicolaus, Stadtmauer, Edward |
| المصدر: | Biology of Blood and Marrow Transplantation; 21(12), pp 2039-2051 (2015) ; ISSN: 1083-8791 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2015 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Hematology |
| الوصف: | In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma Working Group together with the Blood and Marrow Transplant Clinical Trials Network, the American Society of Blood and Marrow Transplantation, and the European Society of Blood and Marrow Transplantation convened a meeting of MM experts to: (1) summarize current knowledge regarding the role of autologous or allogeneic HCT in MM patients progressing after primary therapy, (2) propose guidelines for the use of salvage HCT in MM, (3) identify knowledge gaps, (4) propose a research agenda, and (5) develop a collaborative initiative to move the research agenda forward. After reviewing the available data, the expert committee came to the following consensus statement for salvage autologous HCT: (1) In transplantation-eligible patients relapsing after primary therapy that did NOT include an autologous HCT, high-dose therapy with HCT as part of salvage therapy should be considered standard; (2) High-dose therapy and autologous HCT should be considered appropriate therapy for any patients relapsing after primary therapy that includes an autologous HCT with initial remission duration of more than 18 months; (3) High-dose therapy and autologous HCT can be used as a bridging strategy to allogeneic HCT; (4) The role of postsalvage HCT maintenance needs to be explored in the context of well-designed prospective trials that should include new agents, such as monoclonal antibodies, immune-modulating agents, and oral proteasome inhibitors; (5) Autologous HCT consolidation should be explored as a strategy to develop novel conditioning regimens or post-HCT strategies in patients with short (less than 18 months remissions) after primary ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/8159133Test; http://dx.doi.org/10.1016/j.bbmt.2015.09.016Test; pmid:26428082; wos:000364981700003; scopus:84947430469 |
| DOI: | 10.1016/j.bbmt.2015.09.016 |
| الإتاحة: | https://doi.org/10.1016/j.bbmt.2015.09.016Test https://lup.lub.lu.se/record/8159133Test |
| رقم الانضمام: | edsbas.50822B14 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bbmt.2015.09.016 |
|---|