دورية أكاديمية
Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study
| العنوان: | Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study |
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| المؤلفون: | C. Paula Lewis-de los Angeles, Paige L. Williams, Lisanne M. Jenkins, Yanling Huo, Kathleen Malee, Kathryn I. Alpert, Kristina A. Uban, Megan M. Herting, John G. Csernansky, Sharon L. Nichols, Russell B. Van Dyke, Elizabeth R. Sowell, Lei Wang |
| المصدر: | NeuroImage: Clinical, Vol 26, Iss , Pp - (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Perinatally-acquired HIV, Neurodevelopment, Grey matter, Brain, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Youth with perinatally-acquired HIV (PHIV) experience specific and global cognitive deficits at increased rates compared to typically-developing HIV-uninfected youth. In youth with PHIV, HIV infects the brain early in development. Neuroimaging studies have demonstrated altered grey matter morphometry in youth with PHIV compared to typically-developing youth. This study examined cortical thickness, surface area, and gyrification of grey matter in youth (age 11–20 years old) with PHIV (n = 40) from the Pediatric HIV/AIDS Cohort Study (PHACS) compared to typically-developing presumed HIV uninfected and unexposed youth (n = 80) from the Pediatric Imaging, Neurocognition and Genetics Study (PING) using structural magnetic resonance imaging. This study also examined the relationship between grey matter morphometry and age. Youth with PHIV had reduced cortical thickness, surface area, and gyrification compared to typically-developing youth. In addition, an inverse relationship between age and grey matter volume was found in typically-developing youth, but was not observed in youth with PHIV. Longitudinal studies are necessary to understand the neurodevelopmental trajectory of youth with PHIV. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2213158220300838Test; https://doaj.org/toc/2213-1582Test |
| DOI: | 10.1016/j.nicl.2020.102246 |
| الوصول الحر: | https://doaj.org/article/b4cf6047289148a2ad14651517f3ab90Test |
| رقم الانضمام: | edsdoj.b4cf6047289148a2ad14651517f3ab90 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2020.102246 |