Distribution of the phosphorylated form of microtubule associated protein 1B in the fish visual system during optic nerve regeneration
| العنوان: | Distribution of the phosphorylated form of microtubule associated protein 1B in the fish visual system during optic nerve regeneration |
|---|---|
| المؤلفون: | Elena Vecino, Jesús Avila |
| المساهمون: | Universidad del País Vasco, Eusko Jaurlaritza |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Elsevier, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Retinal Ganglion Cells, Superior Colliculi, Neurite, genetic structures, Microtubule-associated protein, Growth Cones, Cyprinidae, Biology, Retinal ganglion, Microtubule, medicine, Animals, Visual Pathways, Axon, Phosphorylation, Retina, General Neuroscience, Brain, Optic Nerve, Denervation, Immunohistochemistry, eye diseases, Ganglion, Nerve Regeneration, medicine.anatomical_structure, nervous system, Optic Nerve Injuries, Optic nerve, sense organs, Neuroscience, Microtubule-Associated Proteins |
| الوصف: | Microtubule associated proteins are a heterogeneous group of proteins that have been implicated in regulating microtubule stability. They play an important role in the organisation of the neuronal cytoskeleton during neurite outgrowth, plasticity and regeneration. The fish visual system presents a considerable degree of plasticity. Thus, the retina grows continually throughout life and the optic nerve regenerates after crush. In the present study, we compared the distribution of the microtubule associated protein 1B in its phosphorylated form (MAP1B-phos) in the normal adult fish visual system with that observed during optic nerve regeneration after adult optic nerve crush using a specific monoclonal antibody mAb-150. Expression of MAP1B-phos was observed in some ganglion cell somata and in developing, growing axons within the control optic nerve. Few immunoreactive terminals were seen in the control optic tectum. After optic nerve crush, we found additional MAP1B-phos expression in regenerating axons throughout the visual system. Our results demonstrate that MAP1B-phos is present in growing and regenerating axons of fish retinal ganglion cells, which suggests that the phosphorylated form of MAP1B may play an important role in developmental and regeneration processes within the fish central nervous system. This work was supported by Universidad del Paı́s Vasco EB 006/99, Gobierno Vasco (PI-1998-81) and DGES (PM97-0047) grants to E.V. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4521a0c6d7d9626aad8daaf71846db2Test http://hdl.handle.net/10261/252147Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d4521a0c6d7d9626aad8daaf71846db2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |