دورية أكاديمية
The CD4-centered universe of human T cell subsets
| العنوان: | The CD4-centered universe of human T cell subsets |
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| المؤلفون: | Geginat J, Paroni M, Facciotti F, Gruarin P, Kastirr I, Caprioli F, Pagani M, Abrignani S |
| المساهمون: | Geginat, J, Paroni, M, Facciotti, F, Gruarin, P, Kastirr, I, Caprioli, F, Pagani, M, Abrignani, S |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | CD4+ memory T cells, T cell differentiation, cytokines, tissue homing |
| الوصف: | Humans are continuously exposed to a high number of diverse pathogens that induce different types of immune responses. Primary pathogen-specific immune responses generate multiple subsets of memory T cells, which provide protection against secondary infections. In recent years, several novel T cell subsets have been identified and have significantly broadened our knowledge about T cell differentiation and the regulation of immune responses. At the same time the rapidly growing number of incompletely characterized T cell subsets has also generated some controversies. We therefore review here the current knowledge on features and functions of human α/β T cell subsets, focusing on CD4+ T cells classified according to cytokine production and tissue localization. The principal helper and regulatory T cell subsets can be identified by a limited number of relevant surface markers, which are an integral part of the T cell differentiation programs because they are directly induced by the relevant lineage-defining transcription factors. In vivo occurring human T cell subsets can thus be purified directly ex vivo from relevant tissues for molecular and functional studies, and represent not only an ideal model to study T cell differentiation, but they also offer important clinical opportunities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24183700; info:eu-repo/semantics/altIdentifier/wos/WOS:000328313100002; volume:25; issue:4; firstpage:252; lastpage:262; numberofpages:11; journal:SEMINARS IN IMMUNOLOGY; http://hdl.handle.net/10281/335341Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84888864643 |
| DOI: | 10.1016/j.smim.2013.10.012 |
| الإتاحة: | https://doi.org/10.1016/j.smim.2013.10.012Test http://hdl.handle.net/10281/335341Test |
| رقم الانضمام: | edsbas.AF1D2178 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.smim.2013.10.012 |
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