The Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes
| العنوان: | The Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes |
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| المؤلفون: | George L. Sen, Jackson Jones, Maria Noutsou, Ying Wang, Yifang Chen, Ji Ling, Jingting Li |
| المصدر: | Cell Reports, Vol 20, Iss 13, Pp 3005-3013 (2017) Cell reports, vol 20, iss 13 |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, skin, SNAI2, Cohesin complex, Chromosomal Proteins, Non-Histone, 1.1 Normal biological development and functioning, Cellular differentiation, Medical Physiology, GRHL3, cohesin, Cell Cycle Proteins, Biology, SMC3, Regenerative Medicine, General Biochemistry, Genetics and Molecular Biology, Article, Chromosome segregation, 03 medical and health sciences, SMC1A, Stem Cell Research - Nonembryonic - Human, Underpinning research, epidermis, Genetics, Humans, Progenitor cell, lcsh:QH301-705.5, Regulation of gene expression, Cohesin, epigenetics, Stem Cells, Cell Differentiation, Non-Histone, Stem Cell Research, Chromatin, Cell biology, Chromosomal Proteins, stem cell, 030104 developmental biology, Epidermal Cells, Genes, lcsh:Biology (General), Stem Cell Research - Nonembryonic - Non-Human, Generic health relevance, Biochemistry and Cell Biology, Stem cell, biological phenomena, cell phenomena, and immunity, gene regulation, Biotechnology |
| الوصف: | Adult stem and progenitor cells are critical for replenishing lost tissue due to injury or normal turnover. How these cells maintain self-renewal and sustain the tissue they populate are areas of active investigation. Here, we show that the cohesin complex, which has previously been implicated in regulating chromosome segregation and gene expression, is necessary to promote epidermal stem and progenitor cell self-renewal through cell-autonomous mechanisms. Cohesin binds to genomic sites associated with open chromatin, including DNase-I-hypersensitive sites, RNA polymerase II, and histone marks such as H3K27ac and H3K4me3. Reduced cohesin expression results in spontaneous epidermal differentiation due to loss of open chromatin structure and expression of key self-renewal genes. Our results demonstrate a prominent role for cohesin in modulating chromatin structure to allow for enforcement of a stem and progenitor cell gene expression program. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2211-1247 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe744317d88e7ba1bceb4b21488f85dTest http://www.sciencedirect.com/science/article/pii/S2211124717312640Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffe744317d88e7ba1bceb4b21488f85d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22111247 |
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