Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury
| العنوان: | Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury |
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| المؤلفون: | Jun Yin, Patricia R. M. Rocco, Wolfgang M. Kuebler, Xiaolin He, Hajera Amatullah, James N. Tsoporis, Tatiana Maron-Gutierrez, Claudia C. dos Santos, Yuexin Shan, Haibo Zhang, Sahil Gupta, John C. Marshall, Amir K. Varkouhi, Ana Paula Teixeira Monteiro |
| المصدر: | Redox Biology, Vol 38, Iss, Pp 101796-(2021) Redox Biology |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Lipopolysaccharides, 0301 basic medicine, Programmed cell death, DJ-1, Lipopolysaccharide, VILI, Ventilator-Induced Lung Injury, Protein Deglycase DJ-1, Clinical Biochemistry, Inflammation, Lung injury, medicine.disease_cause, Biochemistry, Cell Line, PARK7, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Acute lung injury, Animals, Humans, Lung, lcsh:QH301-705.5, lcsh:R5-920, Ventilators, Mechanical, business.industry, Organic Chemistry, respiratory system, Pulmonary edema, medicine.disease, 3. Good health, respiratory tract diseases, Mice, Inbred C57BL, Cellular infiltration, Endothelial stem cell, 030104 developmental biology, chemistry, lcsh:Biology (General), Cancer research, medicine.symptom, business, lcsh:Medicine (General), 030217 neurology & neurosurgery, Oxidative stress, Research Paper |
| الوصف: | Oxidative stress is considered one of the early underlying contributors of acute lung injury (ALI) and ventilator-induced lung injury (VILI). DJ-1, also known as PARK7, has a well-established role as an antioxidant. We have previously shown maintaining oxidative balance via the ATF3-Nrf2 axis was important in protection from ALI. Here, we exclusively characterize the role of DJ-1 in sterile LPS-induced ALI and VILI. DJ-1 protein expression was increased after LPS treatment in human epithelial and endothelial cell lines and lungs of wild-type mice. DJ-1 deficient mice exhibited greater susceptibility to LPS-induced acute lung injury as demonstrated by increased cellular infiltration, augmented levels of pulmonary cytokines, enhanced ROS levels and oxidized by-products, increased pulmonary edema and cell death. In a two-hit model of LPS and mechanical ventilation (MV), DJ-1 deficient mice displayed enhanced susceptibility to inflammation and lung injury. Collectively, these results identify DJ-1 as a negative regulator of ROS and inflammation, and suggest its expression protects from sterile lung injury driven by high oxidative stress. Graphical abstract Image 1 Highlights • Oxidative stress contributes to acute- and ventilator-induced lung injury. • DJ-1 deficiency increased susceptibility to LPS- and ventilator-induced lung injury. • DJ-1 as antioxidant protects from sterile lung injury driven by high oxidative stress. |
| اللغة: | English |
| تدمد: | 2213-2317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b051190f38305f4146f08b43bd015a89Test http://www.sciencedirect.com/science/article/pii/S2213231720310016Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b051190f38305f4146f08b43bd015a89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22132317 |
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