التفاصيل البيبلوغرافية
العنوان:
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
المؤلفون:
Nicolas Chomont , Vikram Mehraj , Stéphane Isnard , Franck P. Dupuy , Rosalie Ponte , Amélie Pagliuzza , Éric A. Cohen , Augustine Fert , Jean-Pierre Routy , Petronela Ancuta , Delphine Planas , Laurence Raymond Marchand , Mager Peter Ghali , Sylvie Lesage , Marta Massanella , Jonathan B. Angel , Jean-Philippe Goulet , Annie Gosselin
المساهمون:
Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie
المصدر:
EBioMedicine, Vol 65, Iss, Pp 103270-(2021)
بيانات النشر:
Elsevier, 2021.
سنة النشر:
2021
مصطلحات موضوعية:
0301 basic medicine , HIV reservoirs , lcsh:Medicine , Inflammation , C-C chemokine receptor type 6 , Pharmacology , General Biochemistry, Genetics and Molecular Biology , 03 medical and health sciences , 0302 clinical medicine , medicine , Mechanistic target of rapamycin , PI3K/AKT/mTOR pathway , lcsh:R5-920 , biology , business.industry , Surrogate endpoint , lcsh:R , General Medicine , Metformin , 3. Good health , 030104 developmental biology , 030220 oncology & carcinogenesis , biology.protein , mTOR , Phosphorylation , Th17 , medicine.symptom , business , lcsh:Medicine (General) , CD8 , ART , medicine.drug
الوصف:
Background: Chronic inflammation and residual HIV transcription persist in people living with HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing non-AIDS co-morbidities. The mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism and HIV transcription, and therefore represents an interesting novel therapeutic target. Methods: The LILAC pilot clinical trial, performed on non-diabetic ART-treated PLWH with CD4+/CD8+ T-cell ratios
وصف الملف:
application/pdf
اللغة:
English
تدمد:
2352-3964
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce8ca11e9cde49dbdfb48fc3b8820f1Test http://www.sciencedirect.com/science/article/pii/S2352396421000633Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....6ce8ca11e9cde49dbdfb48fc3b8820f1
قاعدة البيانات:
OpenAIRE
