المؤلفون: A Mörner, Lars Lindquist, K Widgren, L Persson Berg, Anders Tegnell, Marie Studahl, Johan Giesecke

المصدر: International Journal of Infectious Diseases, Vol 111, Iss, Pp 92-98 (2021)

مصطلحات موضوعية: Adult, Microbiology (medical), Herpesvirus 3, Human, Pediatrics, medicine.medical_specialty, Adolescent, Seroprevalence, Disease, Infectious and parasitic diseases, RC109-216, Skin infection, Chickenpox Vaccine, Chickenpox, medicine, Humans, Child, Sweden, business.industry, Vaccination, Infant, General Medicine, Seroepidemiologic Studies, medicine.disease, Serum samples, Seroepidemiologic studies, Hospitalization, Infectious Diseases, business, Complication

الوصف: Objectives: To describe the current panorama of severe chickenpox disease and seroprevalence in Sweden, as a basis for the approaching decision on universal vaccination. Methods: Patients discharged with an International Classification of Diseases 10th revision-code for chickenpox (B01-B01.9) in eight pediatric and infectious diseases departments in Stockholm and Gothenburg in 2012-2014 were included in the study and their medical charts were reviewed. Further, residual serum samples collected from 11 laboratories across Sweden were analyzed for varicella zoster IgG-antibodies to investigate age-specific seroprevalence. Results: A total of 218 children and 46 adults were included in this hospital-based study; 87.2% of children and 63.0% of adults had complications. An underlying condition was not associated with an increased risk of complication. Dehydration (31.7%), bacterial skin infections (29.8%) and neurological involvement (20.6%) were the most frequent complications in children. Among adult cases, 63% were born abroad. The seroepidemiological analysis included 957 patient samples. Seroprevalence was 66.7% at 5 years and 91.5% at 12 years. Infants and adolescents/adults were overrepresented among admitted patients compared to seroprevalence data. Conclusions: Half of all complications in hospitalized chickenpox cases were seen in previously healthy children, which supports universal childhood vaccination. Adult migrants was a risk group for chickenpox hospitalization. Age-specific seroprevalence was similar to neighboring countries.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c946efc423777f9aca923ee0b2bbe48Test
http://www.sciencedirect.com/science/article/pii/S1201971221006445Test

المؤلفون: Joseph J. Vettukattil, Ellen M. Lindquist, Weihua Zhou, Sana K. Khan, Jingfeng Jiang, Jordan M. Gosnell, John L. Byl

المصدر: Annals of 3D Printed Medicine, Vol 4, Iss, Pp 100034-(2021)

مصطلحات موضوعية: Clinical cardiology, Multiple image, medicine.medical_specialty, Computer science, business.industry, 3D printing, General Medicine, Augmented reality, Surgical procedures, Cardiovascular disease, Data visualization, AI, Internal medicine, Diagnosis, Cardiology, medicine, Medical technology, R855-855.5, business, Cardiac imaging

الوصف: With the rate of cardiovascular diseases in the U.S increasing throughout the years, there is a need for developing more advanced treatment plans that can be tailored to specific patients and scenarios. The development of 3D printing is rapidly gaining acceptance into clinical cardiology. In this review, key technologies used in 3D printing are briefly summarized, particularly, the use of artificial intelligence (AI), open-source tools like MeshLab and MeshMixer, and 3D printing techniques such as fused deposition molding (FDM) and polyjet are reviewed. The combination of 3D printing, multiple image integration, and augmented reality may greatly enhance data visualization during diagnosis, treatment planning, and surgical procedures for cardiology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2549d7d0dabcafbbf8969cbba0130b9bTest
http://www.sciencedirect.com/science/article/pii/S2666964121000291Test

المؤلفون: Anna Middleton, Anthea Lindquist, Susan P. Walker, Benjamin Koete, Roxanne Hastie, Joshua P. Vogel, Leeanne Panisi, Manarangi De Silva, Catherine Cluver, Stephen Tong

المصدر: The Lancet Regional Health. Western Pacific, Vol 14, Iss, Pp 100217-(2021)
The Lancet Regional Health: Western Pacific

مصطلحات موضوعية: MEDLINE, Near miss, LMIC, Internal Medicine, Medicine, Socioeconomic status, Eclampsia, business.industry, Health Policy, Asia-Pacific, Public Health, Environmental and Occupational Health, Obstetrics and Gynecology, Maternal death, medicine.disease, Near-miss, Uterine rupture, Psychiatry and Mental health, Infectious Diseases, Meta-analysis, Pediatrics, Perinatology and Child Health, Cohort, Geriatrics and Gerontology, Public aspects of medicine, RA1-1270, business, Research Paper, Demography, Maternal morbidity

الوصف: Background: Monitoring rates of severe maternal morbidity (such as eclampsia and uterine rupture) is useful to assess the quality of obstetric care, particularly in low and lower-middle-income countries (LMICs). Methods: We undertook a systematic review characterising the proportion and causes of severe maternal morbidity in the Asia Pacific region. We searched Medline, Embase, Cochrane CENTRAL library and the World Health Organization Western Pacific Index database for studies in the Asia-Pacific reporting maternal morbidity/near miss using a predefined search strategy. We included cohort, case-control and cross-sectional studies published in English before September 2020. A meta-analysis was performed calculating the overall proportion of near miss events by sub-region, country, near miss definition, economic status, setting and cause using a random-effects model. Findings: We identified 26,232 articles, screened 24,306 and retrieved 454 full text articles. Of these, 197 studies spanning 27 countries were included. 13 countries in the region were not represented. There were 30,183,608 pregnancies and 100,011 near misses included. The total proportion of near miss events was 4•4 (95% CI 4•3-4•5) per 1000 total births. The greatest proportion of near misses were found in the Western Pacific region (around Papua New Guinea) at 11•8 per 1000 births (95% CI 6•6-17•1; I2 96.05%). Low-income countries displayed the greatest proportion of near misses (13•4, 95% CI 6•0-20•7), followed by lower-middle income countries (11•1; 95% CI 10•4 - 11•9). High-income countries had the lowest proportion (2•2, 95% CI 2•1-2•3). Postpartum haemorrhage was the most common near miss event (5•9, 95% CI 4•5-7•2), followed by eclampsia (2•7, 95% CI 2•4 - 2•9). Interpretation: There is a high burden of severe maternal morbidity in the Asia-Pacific. LMICs are disproportionately affected. Most of the common causes are preventable. This provides an opportunity to implement targeted interventions which could have major clinical impact.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6fb7d2c61035457666b4e2033dbdfbTest
http://www.sciencedirect.com/science/article/pii/S2666606521001267Test

المؤلفون: Nikolaos-Taxiarchis Skenteris, Hong Jin, Joy Roy, Teodora Andonova, Kenneth Caidahl, Moritz Lindquist-Liljeqvist, Magnus Bäck, Silke Thul, Marcelo H. Petri, Lars Maegdefessel, Mauro Perretti, Hildur Arnardottir

المصدر: JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 719-727 (2018)
JACC: Basic to Translational Science

مصطلحات موضوعية: ATL, aspirin-triggered lipoxin, 0301 basic medicine, Pathology, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Inflammation, 030204 cardiovascular system & hematology, eicosanoids, Formyl peptide receptor 2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, cardiovascular disease, Adventitia, LEADING EDGE IN TRANSLATIONAL RESEARCH, LX, lipoxin, medicine, Receptor, Protein kinase A, ALX/FPR2, A lipoxin/formyl peptide receptor 2, Ang II, angiotensin II, Lipoxin, abdominal aortic aneurysms, AAA, abdominal aortic aneurysm, business.industry, Rv, resolvin, LO, lipoxygenase, SPM, specialized pro-resolving mediators, medicine.disease, lipoxygenase, Angiotensin II, Abdominal aortic aneurysm, 030104 developmental biology, medicine.anatomical_structure, chemistry, inflammation, lcsh:RC666-701, cardiovascular system, medicine.symptom, Cardiology and Cardiovascular Medicine, business

الوصف: Visual Abstract
Highlights • Specialized lipid mediators transduce the resolution of inflammation by means of the ALX/FPR2. • Human AAA exhibited decreased ALX/FPR2 expression. • Genetic disruption of the murine ALX/FPR2 ortholog exacerbated AAA and increased inflammation. • The ALX/FPR2 agonist ATL induced pro-resolving signaling in bone marrow-derived murine cells. • Pro-resolving signaling by means of the ALX/FPR2 receptor may decrease the progression of AAA.
Summary An abdominal aortic aneurysm (AAA) is a progressive aortic dilation that may lead to rupture, which is usually lethal. This study identifies the state of failure in the resolution of inflammation by means of decreased expression of the pro-resolving receptor A lipoxin/formyl peptide receptor 2 (ALX/FPR2) in the adventitia of human AAA lesions. Mimicking this condition by genetic deletion of the murine ALX/FPR2 ortholog in hyperlipidemic mice exacerbated the aortic dilation induced by angiotensin II infusion, associated with decreased vascular collagen and increased inflammation. The authors also identified key roles of lipoxin formation through 12/15-lipoxygenase and neutrophil p38 mitogen-activated protein kinase. In conclusion, this study established pro-resolving signaling by means of the ALX/FPR2 receptor in aneurysms and vascular inflammation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12417e5c91c925f572b8acb0220bd5bTest
http://www.sciencedirect.com/science/article/pii/S2452302X18302249Test

المؤلفون: Jonathan J. Y. Ong, Amanda C. Chan, Vijay Sharma, Carin D. Lindquist, Matthew T. Silvestrini, Michelle S. M. Rhee

المصدر: Journal of Infection and Public Health, Vol 14, Iss 7, Pp 947-948 (2021)

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Public Health, Environmental and Occupational Health, MEDLINE, General Medicine, Infectious and parasitic diseases, RC109-216, medicine.disease, Health personnel, Infectious Diseases, Health care, Medicine, Medical emergency, Public aspects of medicine, RA1-1270, business, Personal protective equipment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08db7ee836253e4f2c2f7afa67044b7aTest
http://www.sciencedirect.com/science/article/pii/S1876034121000964Test

المؤلفون: Kel Markert, K. Tenneson, Marija Kono, David Saah, Giang Vu Nguyen, Peter Potapov, Chansopheaktra Sovann, Soukanh Bounthabandit, Su Mon Myat, Farrukh Chishtie, Jeffrey Silverman, Sajana Maharjan, Birendra Bajracharya, Jeremy Broadhead, Ate Poortinga, Erik Lindquist, Kabir Uddin, Matthew Patterson, Ian W. Housman, Mir A. Matin, Phuong M. Do, Radhika Bhargava, Peter Cutter, Africa Ixmucane Flores-Anderson, Biplov Bhandari, Nicholas Clinton, P. Towashiraporn, Walter L. Ellenberg, Joshua Goldstein, Eric Anderson, Hai N. Pham, Nishanta Khanal, Raja Ram Aryal, Kei Sato, David J. Ganz, Paul Maus, K. S. Aung, Quyen Nguyen

مصطلحات موضوعية: Global and Planetary Change, 010504 meteorology & atmospheric sciences, Database, Computer science, business.industry, Suite, 0211 other engineering and technologies, Decision tree, Context (language use), 02 engineering and technology, Land cover, Management, Monitoring, Policy and Law, Modular design, computer.software_genre, 01 natural sciences, Key (cryptography), Computers in Earth Sciences, Architecture, business, computer, Smoothing, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, Earth-Surface Processes

الوصف: Land cover maps play an integral role in environmental management. However, countries and institutes encounter many challenges with producing timely, efficient, and temporally harmonized updates to their land cover maps. To address these issues we present a modular Regional Land Cover Monitoring System (RLCMS) architecture that is easily customized to create land cover products using primitive map layers. Primitive map layers are a suite of biophysical and end member maps, with land cover primitives representing the raw information needed to make decisions in a dichotomous key for land cover classification. We present best practices to create and assemble primitives from optical satellite using computing technologies, decision tree logic and Monte Carlo simulations to integrate their uncertainties. The concept is presented in the context of a regional land cover map based on a shared regional typology with 18 land cover classes agreed on by stakeholders from Cambodia, Laos PDR, Myanmar, Thailand, and Vietnam. We created annual map and uncertainty layers for the period 2000–2017. We found an overall accuracy of 94% when taking uncertainties into account. RLCMS produces consistent time series products using free long term historical Landsat and MODIS data. The customizable architecture can include a variety of sensors and machine learning algorithms to create primitives and the best suited smoothing can be applied on a primitive level. The system is transferable to all regions around the globe because of its use of publicly available global data (Landsat and MODIS) and easily adaptable architecture that allows for the incorporation of a customizable assembly logic to map different land cover typologies based on the user’s landscape monitoring objectives keywords: Land cover, Remote sensing, Mekong region, Google Earth Engine, Landsat, SERVIR ispartof: International Journal Of Applied Earth Observation And Geoinformation vol:85 pages:101979-101979 status: Published online

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8e8fb8aa21ced469565b959cf8b8baTest
https://lirias.kuleuven.be/handle/20.500.12942/703464Test

المؤلفون: Sofi Isaksson, Bassam Hazem, Håkan Griph, Gudrun N. Oskarsdottir, Per Levéen, Ronny Öhman, Johan Staaf, Anders Edsjö, Hans Brunnström, Jens Engleson, Karin Annersten, Karolina Holm, Kajsa Ericson Lindquist, Göran Jönsson, Mats Jönsson, Maria Planck, Frida Rosengren, Anna Karlsson, Christel Reuterswärd, Åke Borg

المصدر: JTO Clinical and Research Reports
JTO Clinical and Research Reports, Vol 1, Iss 1, Pp 100013-(2020)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, medicine.medical_treatment, Disease, medicine.disease_cause, lcsh:RC254-282, Exon, Internal medicine, medicine, Chemotherapy, Lung cancer, Lung, Massive parallel sequencing, business.industry, Never smoker, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, Mutation testing, Original Article, KRAS, Driver oncogenes, business

الوصف: Objectives Mutation analysis by massive parallel sequencing (MPS) is routinely performed in the clinical management of lung cancer in Sweden. We describe the clinical and mutational profiles of lung cancer patients subjected to the first 1.5 years of treatment predictive MPS testing in an autonomous regional health care region. Methods Tumors from all patients with lung cancer who had an MPS test from January 2015 to June 2016 in the Skane health care region in Sweden (1.3 million citizens) were included. Six hundred eleven tumors from 599 patients were profiled using targeted sequencing with a 26-gene exon-focused panel. Data on disease patterns and characteristics of the patients subjected to testing were assembled, and correlations between mutational profiles and clinical features were analyzed. Results MPS with the 26-gene panel revealed alterations in 92% of the 611 lung tumors, with the most frequent mutations detected in the nontargetable genes TP53 (62%) and KRAS (37%). Neither KRAS nor TP53 mutations were associated with disease pattern, chemotherapy response, progression-free survival, or overall survival in advanced-stage disease treated with platinum-based doublet chemotherapy as a first-line treatment. Among targetable genes, EGFR driver mutations were detected in 10% of the tumors, and BRAF p.V600 variants in 2.3%. For the 71 never smokers (12%), targetable alterations (EGFR mutations, BRAF p.V600, MET exon 14 skipping, or ALK/ROS1 rearrangement) were detected in 59% of the tumors. Conclusion Although the increasing importance of MPS as a predictor of response to targeted therapies is indisputable, its role in prognostics or as a predictor of clinical course in nontargetable advanced stage lung cancer requires further investigation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232effa39270280f632e46dd1f19ad7eTest
http://europepmc.org/articles/PMC8474272Test

المؤلفون: Martin A. Lindquist

مصطلحات موضوعية: Resting state fMRI, medicine.diagnostic_test, business.industry, Brain activity and meditation, Inference, Pattern recognition, Human brain, computer.software_genre, Data acquisition, medicine.anatomical_structure, medicine, Preprocessor, Data mining, Artificial intelligence, Time series, Functional magnetic resonance imaging, business, Psychology, computer

الوصف: The study of human brain function using functional magnetic resonance imaging (fMRI) has exploded in the past decade. A standard fMRI study results in enormous amounts of data. In addition, the signal of interest is relatively weak and the data exhibit a complicated temporal and spatial noise structure. In this article, we provide an overview of the analysis of fMRI data, from the initial data acquisition to its use in locating brain activity, making inference about brain connectivity and predictions about psychological or disease states.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::339ed0f33ed8bd9b3e2917b09ccd089fTest
https://doi.org/10.1016/b978-0-08-097086-8.42004-0Test

المؤلفون: Helena Lindquist

مصطلحات موضوعية: business.industry, Economic policy, Directive, Energy policy, Renewable energy, Electricity generation, Economy, Economics, media_common.cataloged_instance, Electricity, European union, business, Feed-in tariff, Externality, media_common

الوصف: Following far-reaching policy initiatives by the European Union (EU) in 2009, electricity production from renewable energy sources is rapidly increasing as European countries are struggling to meet the targets of the European Renewable Energy Directive. Europe is vulnerable to externalities, such as the emergence of shale gas on the global energy market, which may fundamentally alter the basis for EU energy policy. Integration of renewables in European electrical power grids presents an urgent and multi-faceted challenge for policy-makers and sector stakeholders requiring coordinated measures for grid upgrades, development of grid codes and radical reform of electricity markets. Some European countries, e.g. Denmark, Germany and the UK, are in many respects frontrunners in starting the transition to a more sustainable energy system. Their experiences and examples of best practice provide important learning for other countries in Europe and the world.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ee53fd6a7ac804fb275d587fa74807a6Test
https://doi.org/10.1016/b978-0-12-407910-6.00001-6Test

المؤلفون: Thomas D. Lindquist

المصدر: Corneal Surgery ISBN: 9780323048354
Corneal Surgery

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Ophthalmology, medicine.medical_treatment, Medicine, Intraocular lens, business, Pseudophakic bullous keratopathy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b831e409f623d301edfb3f30596450a1Test
https://doi.org/10.1016/b978-0-323-04835-4.50053-7Test