Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1
| العنوان: | Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1 |
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| المؤلفون: | Arnaud Delpoux, Stephen M. Hedrick, Dominik Wieland, Maike Hofmann, Xin Huang, Daniel T. Utzschneider, Robert Thimme, Chen-Yen Lai |
| المصدر: | Cell Reports, Vol 22, Iss 13, Pp 3454-3467 (2018) Cell reports, vol 22, iss 13 |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, T-Lymphocytes, Medical Physiology, FOXO1, Inbred C57BL, self-renewal, immune memory, Mice, 0302 clinical medicine, Leukocytes, 2.1 Biological and endogenous factors, homeostatic proliferation, Aetiology, lcsh:QH301-705.5, education.field_of_study, Forkhead Box Protein O1, TCF1/TCF7, 3. Good health, Infectious Diseases, medicine.anatomical_structure, Acute Disease, Infection, endocrine system, T cell, Population, Mononuclear, T cells, Biology, cell survival, General Biochemistry, Genetics and Molecular Biology, Article, Vaccine Related, 03 medical and health sciences, Immunity, Biodefense, Genetics, medicine, Animals, Humans, quiescence, education, LCMV, Transcription factor, Innate immune system, Prevention, chronic infection, Mice, Inbred C57BL, Chronic infection, Emerging Infectious Diseases, 030104 developmental biology, lcsh:Biology (General), Immunology, Chronic Disease, Leukocytes, Mononuclear, FOXO, Biochemistry and Cell Biology, Immunologic Memory, CD8, 030215 immunology |
| الوصف: | Summary: Immunity following an acutely resolved infection or the long-term equipoise of chronic viral infections often depends on the maintenance of antigen-specific CD8+ T cells, yet the ongoing transcriptional requirements of these cells remain unclear. We show that active and continuous programming by FOXO1 is required for the functional maintenance of a memory population. Upon Foxo1 deletion following resolution of an infection, memory cells rapidly lost their characteristic gene expression, gradually declined in number, and were impaired in self-renewal. This was extended to chronic infections, as a loss of FOXO1 during a persistent viral infection led to a rapid decline of the TCF7 (a.k.a. TCF1)-expressing memory-like subset of CD8+ T cells. We further establish FOXO1 regulation as a characteristic of human memory CD8+ T cells. Overall, we show that the molecular and functional longevity of a memory T cell population is actively maintained by the transcription factor FOXO1. : Utzschneider et al. find that hallmarks of CD8+ T cell memory such as longevity, self-renewal, and the ability to cycle between quiescence and cell division depend on continued expression of FOXO1. Loss of FOXO1 during any of these stages leads to the interruption of T cell memory. Keywords: immune memory, homeostatic proliferation, self-renewal, quiescence, cell survival, T cells, FOXO, TCF1/TCF7, chronic infection, LCMV |
| اللغة: | English |
| تدمد: | 2211-1247 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d33eeb9aa9cd37b0a0b64e7e1532570Test http://www.sciencedirect.com/science/article/pii/S2211124718303498Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d33eeb9aa9cd37b0a0b64e7e1532570 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22111247 |
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