Interstitial Pneumonia in Psoriasis
| العنوان: | Interstitial Pneumonia in Psoriasis |
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| المؤلفون: | Shunsuke Minagawa, Hidemi Nakagawa, Hironori Kawamoto, Yoshinori Umezawa, Jun Araya, Hiromichi Hara, Kazuyoshi Kuwano, Akihiko Asahina, Yumi Kaneko, Takanori Numata |
| المصدر: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 2, Iss 4, Pp 370-377 (2018) Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, SEC, secukinumab, Radiography, IP, interstitial pneumonia, UST, ustekinumab, Gastroenterology, Pathogenesis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Psoriasis, Ustekinumab, medicine, 030212 general & internal medicine, lcsh:R5-920, Lung, business.industry, Interleukin, PASI, psoriasis area severity index, medicine.disease, CT, computed tomography, IL, interleukin, KL-6, Krebs von den Lungen-6, medicine.anatomical_structure, Reticular connective tissue, Secukinumab, Original Article, business, lcsh:Medicine (General), medicine.drug |
| الوصف: | Objective To investigate the relationship between psoriasis and interstitial pneumonia (IP). Patients and Methods We analyzed the clinical data of patients with psoriasis treated with biologic agents from June 1, 2008, to June 30, 2017, retrospectively. Chest computed tomography was performed in 392 patients before treatment. The clinical characteristics and radiographic findings of these patients were evaluated. Results Of the 392 patients with psoriasis, IP was detected in 8 patients (2%). Bilateral ground-glass and/or irregular linear (reticular) opacity in the lower lung zone was the most common chest computed tomography finding. Five of the 8 patients with IP were treated with anti–interleukin (IL) 12/IL-23 or IL-17 antibodies, leading to decreased or stable IP activity. Conclusion Interstitial pneumonia was detected in 2% of patients with psoriasis who needed systemic treatments. Ground-glass and/or irregular linear (reticular) opacity in the bilateral lower lobes was characteristic of IP with psoriasis. The IL-23/IL-17 axis may play important roles in the pathogenesis of IP in psoriasis. |
| اللغة: | English |
| تدمد: | 2542-4548 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba94f9cfc03536aafe6f801de754431eTest http://www.sciencedirect.com/science/article/pii/S2542454818300857Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ba94f9cfc03536aafe6f801de754431e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25424548 |
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