نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

1

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

المؤلفون: Shweta Urva, Julie S. Moyers, Krister Bokvist, Kyle W. Sloop, Jorge Alsina-Fernandez, William C. Roell, Charles Benson, Uma Kuchibhotla, David A. D'Alessio, Corina Loghin, Xuewei Cui, Tamer Coskun, Over Cabrera, Daniel A. Briere, Ruth E. Gimeno, Axel Haupt

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 18, Iss, Pp 3-14 (2018)

مصطلحات موضوعية: 0301 basic medicine, ipGTT, Intraperitoneal glucose tolerance test, LY3298176, ADA, Antidrug antibodies, Receptor agonist activity, Pharmacology, 0302 clinical medicine, Glucagon-Like Peptide 1, Medicine, OGTT, Oral glucose tolerance test, Receptor, T2DM, Type 2 diabetes mellitus, CNS, Central nervous system, ECG, Electrocardiogram, SMBG, Self-monitored blood glucose, Glucagon-like peptide-1, SAD, Single-ascending dose, LY, LY3298176, Original Article, medicine.drug, Agonist, POC, Proof-of-concept, lcsh:Internal medicine, Glucose-dependent insulinotropic polypeptide, medicine.drug_class, Incretin, 030209 endocrinology & metabolism, GLP-1 RA, Glucagon-like peptide-1 receptor agonist, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Metabolic Diseases, PL, PPlacebo, Diabetes mellitus, Type 2 diabetes mellitus, Humans, DU, Dulaglutide, Obesity, GIP, Glucose-dependent insulinotropic polypeptide, lcsh:RC31-1245, Molecular Biology, MAD, Multiple-ascending dose, Glucagon-like peptide 1 receptor, business.industry, CI, Confidence interval, Cell Biology, medicine.disease, DIO, Diet-induced obesity, 030104 developmental biology, HS, Healthy subjects, Diabetes Mellitus, Type 2, MMRM, Mixed model for repeated measures, Dulaglutide, business, LSM, Least square mean

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ca485dc3a86e98e8a5c2fbb364cd27Test
http://europepmc.org/articles/PMC6308032Test

2

Glucagon-like peptide 1 (GLP-1)

المساهمون: Gribble, Fiona [0000-0002-4232-2898], Reimann, Frank [0000-0001-9399-6377], Apollo - University of Cambridge Repository

المصدر: Molecular Metabolism, Vol 30, Iss, Pp 72-130 (2019)
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010Test

مصطلحات موضوعية: Blood Glucose, 0301 basic medicine, endocrine system, lcsh:Internal medicine, medicine.medical_treatment, Incretin, 030209 endocrinology & metabolism, Review, Gastric Inhibitory Polypeptide, Pharmacology, Neuroprotection, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, GLP-1, Insulin, Glucagon, Diabetes, Obesity, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Diabetes mellitus, Insulin Secretion, Receptors, Glucagon, medicine, Humans, Hypoglycemic Agents, ddc:610, Receptor, lcsh:RC31-1245, Molecular Biology, 2. Zero hunger, Gastric emptying, business.industry, digestive, oral, and skin physiology, Cell Biology, medicine.disease, Glucagon-like peptide-1, ddc, 3. Good health, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, business, hormones, hormone substitutes, and hormone antagonists, Hormone

وصف الملف: application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149f479672bca71b4b53a62f98002f48Test
http://www.sciencedirect.com/science/article/pii/S2212877819309135Test

3

Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?

المؤلفون: Anna Veelen, Patrick Schrauwen, Edmundo Erazo-Tapia, Jan Oscarsson

المصدر: Molecular Metabolism, Vol 46, Iss, Pp 101158-(2021)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, lcsh:Internal medicine, β-cell function, Beta-cell Function, 030209 endocrinology & metabolism, Disease, Type 2 diabetes, Review, Bioinformatics, Diabetes treatment, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Diabetes mellitus, Insulin-Secreting Cells, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, lcsh:RC31-1245, Molecular Biology, Sodium-Glucose Transporter 2 Inhibitors, Dipeptidyl-Peptidase IV Inhibitors, business.industry, Insulin sensitivity, Cell Biology, medicine.disease, Diabetes classification, 030104 developmental biology, Diabetes Mellitus, Type 2, Hyperglycemia, Thiazolidinediones, Personalised medicine, Personalized medicine, Insulin Resistance, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79048df79416fec889894404372ce2e1Test
http://www.sciencedirect.com/science/article/pii/S2212877820302325Test

4

Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease

المؤلفون: Daniel J. Drucker, Laurie L. Baggio

المصدر: Molecular Metabolism, Vol 46, Iss, Pp 101090-(2021)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, endocrine system, lcsh:Internal medicine, Glucagon-Like Peptides, Amylin, Adipose tissue, 030209 endocrinology & metabolism, Gastric Inhibitory Polypeptide, Review, Type 2 diabetes, Disease, Bioinformatics, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, 0302 clinical medicine, Metabolic Diseases, Weight loss, Diabetes mellitus, Weight Loss, medicine, Animals, Humans, Hypoglycemic Agents, Obesity, lcsh:RC31-1245, Molecular Biology, Glycemic, business.industry, Semaglutide, Diabetes, Cell Biology, medicine.disease, Cardiovascular disease, 3. Good health, Fatty Liver, 030104 developmental biology, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Peptide, medicine.symptom, Steatohepatitis, business, Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d14938c81b7fabbd8f8ba7aa035359Test
http://www.sciencedirect.com/science/article/pii/S2212877820301642Test

5

Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice

المؤلفون: Christopher J. Rhodes, R. Leigh Townsend, Sangho Yu, Hans-Rudolf Berthoud, James L. Trevaskis, Michael B. Mumphrey, Stephanie Oldham, Brandon B. Boland, Zheng Hao, Sarah Will, Heike Münzberg, Benji Gill, Christopher D. Morrison

المصدر: Molecular Metabolism, Vol 25, Iss, Pp 64-72 (2019)
Molecular Metabolism

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Bariatric Surgery, medicine.disease_cause, Receptors, G-Protein-Coupled, Mice, 0302 clinical medicine, Insulin, Glucose homeostasis, Medicine, Mice, Knockout, 2. Zero hunger, Diabetes, Glucose tolerance, Insulin tolerance, 3. Good health, Original Article, Signal transduction, medicine.medical_specialty, lcsh:Internal medicine, Gastric Bypass, 030209 endocrinology & metabolism, Diet, High-Fat, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Metabolic Diseases, Diabetes mellitus, Animals, Peptide YY, Obesity, lcsh:RC31-1245, Molecular Biology, PYY, business.industry, Gastric bypass surgery, Body Weight, Wild type, Cell Biology, medicine.disease, Blockade, Surgery, Mice, Inbred C57BL, 030104 developmental biology, Gene Expression Regulation, Insulin Resistance, Energy Metabolism, Transcriptome, GLP-1, business, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560ece653d077ad2f9e5615bfb2a03fdTest
http://www.sciencedirect.com/science/article/pii/S2212877819302339Test

6

Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

المؤلفون: Jenna Holland, Belen Rivero-Gutierrez, Diego Perez-Tilve, Radha Khrisna, April Haller, David A. D'Alessio, Emily Yates, Richard D. DiMarchi, Kirk M. Habegger

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 17, Iss, Pp 28-38 (2018)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Blood Glucose, Male, lcsh:Internal medicine, medicine.medical_specialty, endocrine system diseases, medicine.drug_class, medicine.medical_treatment, Glucagon, Glucagon-Like Peptide-1 Receptor, Streptozocin, Diabetes Mellitus, Experimental, 03 medical and health sciences, Mice, Internal medicine, Diabetes mellitus, Insulin-Secreting Cells, Gene expression, medicine, Receptors, Glucagon, Insulin, Animals, lcsh:RC31-1245, Molecular Biology, GLP-1R, Mice, Knockout, GCGR, business.industry, Diabetes, nutritional and metabolic diseases, Cell Biology, Streptozotocin, medicine.disease, Tamoxifen, Disease Models, Animal, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Hyperglycemia, Original Article, business, Transcriptome, Glucagon receptor, medicine.drug, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fd800bfe071b35b409248b56a7b526Test
http://europepmc.org/articles/PMC6197675Test

7

Cardiovascular, mortality and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

المؤلفون: Søren Lund Kristensen, Pardeep S. Jhund, Lars Køber, David Preiss, Rasmus Rørth, Naveed Sattar, John J.V. McMurray, Kieran F. Docherty, Mark C. Petrie

المصدر: Kristensen, S L, Rørth, R, Jhund, P S, Docherty, K F, Sattar, N, Preiss, D, Køber, L, Petrie, M C & McMurray, J J V 2019, ' Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes : a systematic review and meta-analysis of cardiovascular outcome trials ', The Lancet Diabetes and Endocrinology, vol. 7, no. 10, pp. 776-785 . https://doi.org/10.1016/S2213-8587Test(19)30249-9

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ab17877e975e7d9792dcc5da1b734bTest
https://eprints.gla.ac.uk/190412/7/190412.pdfTest

8

'Let's Stay Together'; GIP and GLP-1 dual agonism in the treatment of metabolic disease

المؤلفون: Richard D. DiMarchi

المصدر: Molecular Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc5e31bcd58e31bb5065e755a97ab52Test
http://europepmc.org/articles/PMC6309716Test

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