Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells
| العنوان: | Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells |
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| المؤلفون: | Gisela Gerardi, Raquel Del Pino-García, Pilar Muñiz, María Luisa González-Sanjosé, Javier García-Lomillo, María D. Rivero-Pérez |
| المصدر: | Repositorio Institucional de la Universidad de Burgos (RIUBU) instname Journal of Functional Foods, Vol 22, Iss, Pp 431-445 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Bioquímica, Redox signalling, Molecular biology, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Protein oxidation, medicine.disease_cause, Biochemistry, Nitric oxide, Lipid peroxidation, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Alimentos, medicine, Hyperglycaemia, TX341-641, Endothelial dysfunction, Colonic metabolites, chemistry.chemical_classification, Reactive oxygen species, Wine pomace, Nutrition and Dietetics, Biología molecular, biology, Nutrition. Foods and food supply, Pomace, Endothelial function, medicine.disease, Dietary antioxidants, 030104 developmental biology, chemistry, Food, biology.protein, Oxidative stress, Food Science |
| الوصف: | Dietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial function impairment observed in cardiovascular diseases. This study investigates the specific protective effects of a vegetal seasoning obtained from seedless wine pomace against hyperglycaemia-induced oxidative damage and dysfunction in human umbilical vein endothelial cells EA.hy926. Non-cytotoxic doses of the bioactive compounds obtained following in vitro digestion of the seasoning were used as treatments. Digested compounds, especially colonic bacterial metabolites, restored a more balanced redox environment, prevented lipid peroxidation and cell membrane damage, ameliorated protein oxidation, and improved the balance between endothelial reactive oxygen species and nitric oxide production in hyperglycaemic cells. Reduction of angiotensin I-converting enzyme activity and gene modulation of superoxide dismutase, haem oxygenase-1, β-nicotinamide adenine dinucleotide phosphate oxidase-4, and endothelial nitric oxide synthase are proposed as the mechanisms underlying this protection.These results support the potential benefits of functional wine pomace seasonings in vascular complications associated with oxidative stress. Autonomous Government of Castilla y León (Research project BU282U13). The PhD grants of RDPG and JGL (FPU grants AP2010-1933 and FPU12/05494) are funded by the Ministry of Education, Culture and Sports, Spain. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ca7534d70288668b79af6c53b49e2bTest http://hdl.handle.net/10259/4297Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....00ca7534d70288668b79af6c53b49e2b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |