دورية أكاديمية
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
| العنوان: | LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy |
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| المؤلفون: | Delphine Planas, Amélie Pagliuzza, Rosalie Ponte, Augustine Fert, Laurence Raymond Marchand, Marta Massanella, Annie Gosselin, Vikram Mehraj, Franck P Dupuy, Stéphane Isnard, Jean-Philippe Goulet, Sylvie Lesage, Eric A. Cohen, Mager Peter Ghali, Jonathan B. Angel, Nicolas Chomont, Jean-Pierre Routy, Petronela Ancuta |
| المصدر: | EBioMedicine, Vol 65, Iss , Pp 103270- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Metformin, ART, HIV reservoirs, Th17, mTOR, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Chronic inflammation and residual HIV transcription persist in people living with HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing non-AIDS co-morbidities. The mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism and HIV transcription, and therefore represents an interesting novel therapeutic target. Methods: The LILAC pilot clinical trial, performed on non-diabetic ART-treated PLWH with CD4+/CD8+ T-cell ratios |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2352396421000633Test; https://doaj.org/toc/2352-3964Test |
| DOI: | 10.1016/j.ebiom.2021.103270 |
| الوصول الحر: | https://doaj.org/article/b77dad2e089643938c96c3b816fc71fbTest |
| رقم الانضمام: | edsdoj.b77dad2e089643938c96c3b816fc71fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2021.103270 |