دورية أكاديمية
Prevalence Of Malaria And Glucose-6-Phosphate Dehydrogenase Deficiency In Malaria-Endemic Southwestern Uganda: Implications For Primaquine Use
| العنوان: | Prevalence Of Malaria And Glucose-6-Phosphate Dehydrogenase Deficiency In Malaria-Endemic Southwestern Uganda: Implications For Primaquine Use |
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| المؤلفون: | Roh, Michelle |
| المصدر: | Public Health Theses |
| بيانات النشر: | EliScholar – A Digital Platform for Scholarly Publishing at Yale |
| سنة النشر: | 2015 |
| المجموعة: | Yale University: EliScholar |
| مصطلحات موضوعية: | EMD, g6pd deficiency, malaria, prevalence, primaquine, southwestern Uganda |
| الوصف: | Introduction: Malaria transmission in Uganda is remarkably heterogeneous, and declines in prevalence have not been uniform. Previous surveys in southwestern Uganda have shown declines in parasite prevalence from 2004 to 2010. As malaria transmission continues to decline in southwestern Uganda, aggressive strategies, such as the addition of primaquine (PQ) to artemisinin-combination therapies (ACTs), are being considered in low transmission settings. Despite the potential benefit of PQ in reducing transmission, concerns over its safety and efficacy have hampered its deployment. In particular, those with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at a higher risk of hemolytic toxicity. Methods: To better assess how primaquine may impact upon southwestern Uganda, we conducted a cross sectional survey among 631 children under five years of age sampled from districts previously characterized as low (Mbarara), intermediate (Bushenyi), and high (Isingiro) transmission intensities. Blood samples were collected via capillary fingerprick to determine the current status of malaria control and the prevalence of G6PD deficiency. Parasite prevalence was determined using (1) a combined Plasmodium HRP-2/LDH rapid diagnostic test (RDT) (SD Bioline Malaria Ag P.f/Pan) and (2) light microscopy. G6PD deficiency was evaluated by: (1) quantitative G6PD deficiency by spectrophotometric assay (Trinity Biotech®), (2) qualitative G6PD deficiency assay by rapid diagnostic test (CareStart™ G6PD RDT), and (3) DNA was isolated to conduct PCR-RFLP analysis to detect the G6PD A- 202A/376G allele. Results: Prevalence of parasitemia was higher by RDT compared to microscopy (6.2% (95% CI: 4.3-8.1) vs. 3.2% (95% CI: 1.8-4.5)). By district, parasitemia prevalence was 1.2% (3/242) in Mbarara, 3.2% (5/157) in Bushenyi, and 5.2% (12/232) in Isingiro. All 20 microscopy positive cases were detected by RDT. Of the 19 cases detected only by RDT, 7 (36.8%) reported having been treated for malaria within the past month. Notably, of the ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://elischolar.library.yale.edu/ysphtdl/1248Test; https://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1247&context=ysphtdlTest |
| الإتاحة: | https://elischolar.library.yale.edu/ysphtdl/1248Test https://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1247&context=ysphtdlTest |
| رقم الانضمام: | edsbas.EB604F24 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |