دورية أكاديمية
Two complement receptor one alleles have opposing associations with cerebral malaria and interact with ethalassaemia
| العنوان: | Two complement receptor one alleles have opposing associations with cerebral malaria and interact with ethalassaemia |
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| المؤلفون: | Opi, DH, Swann, O, Macharia, A, Uyoga, S, Band, G, Ndila, CM, Harrison, EM, Thera, MA, Kone, AK, Diallo, DA, Doumbo, OK, Lyke, KE, Plowe, CV, Moulds, JM, Shebbe, M, Mturi, N, Peshu, N, Maitland, K, Raza, A, Kwiatkowski, DP, Rockett, KA, Williams, TN, Rowe, JA |
| المساهمون: | Commission of the European Communities, Wellcome Trust |
| بيانات النشر: | eLife Sciences Publications Ltd |
| سنة النشر: | 2018 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, PLASMODIUM-FALCIPARUM MALARIA, KNOPS BLOOD-GROUP, SICKLE-CELL TRAIT, ERYTHROCYTE-MEMBRANE, AFRICAN CHILDREN, KENYAN CHILDREN, POLYMORPHISM, SUSCEPTIBILITY, RESISTANCE, PROTECTION, p. falciparum, Alpha thalassaemia, Cerebral malaria, Complement receptor 1, Knops blood group, epidemiology, global health, human, infectious disease, microbiology |
| الوصف: | Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, consistent with selection by malaria. Previous studies have been inconclusive. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted for confounders, we estimate the relationship between Sl2 and McCb and malaria phenotypes, and find they have opposing associations. The Sl2 polymorphism is associated with markedly reduced odds of cerebral malaria and death, while the McCb polymorphism is associated with increased odds of cerebral malaria. We also identify an apparent interaction between Sl2 and α+thalassaemia, with the protective association of Sl2 greatest in children with normal α-globin. The complex relationship between these three mutations may explain previous conflicting findings, highlighting the importance of considering genetic interactions in disease-association studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | eLife; http://hdl.handle.net/10044/1/60676Test; https://dx.doi.org/10.7554/eLife.31579Test; 242095; 091758/B/10/Z; C163; 202800/Z/16/Z |
| DOI: | 10.7554/eLife.31579 |
| الإتاحة: | https://doi.org/10.7554/eLife.31579Test http://hdl.handle.net/10044/1/60676Test |
| حقوق: | © 2018 Opi et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
| رقم الانضمام: | edsbas.347FFC96 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.31579 |