دورية أكاديمية
Specialized impulse conduction pathway in the alligator heart
| العنوان: | Specialized impulse conduction pathway in the alligator heart |
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| المؤلفون: | Bjarke Jensen, Bastiaan J Boukens, Dane A Crossley II, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera, Igor R Efimov, Vincent M Christoffels |
| المصدر: | eLife, Vol 7 (2018) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | American alligator, conduction system, evolution, Ventricular septum, Tbx3, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Mammals and birds have a specialized cardiac atrioventricular conduction system enabling rapid activation of both ventricles. This system may have evolved together with high heart rates to support their endothermic state (warm-bloodedness) and is seemingly lacking in ectothermic vertebrates from which first mammals then birds independently evolved. Here, we studied the conduction system in crocodiles (Alligator mississippiensis), the only ectothermic vertebrates with a full ventricular septum. We identified homologues of mammalian conduction system markers (Tbx3-Tbx5, Scn5a, Gja5, Nppa-Nppb) and show the presence of a functional atrioventricular bundle. The ventricular Purkinje network, however, was absent and slow ventricular conduction relied on trabecular myocardium, as it does in other ectothermic vertebrates. We propose the evolution of the atrioventricular bundle followed full ventricular septum formation prior to the development of high heart rates and endothermy. In contrast, the evolution of the ventricular Purkinje network is strongly associated with high heart rates and endothermy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/32120Test; https://doaj.org/toc/2050-084XTest |
| DOI: | 10.7554/eLife.32120 |
| الوصول الحر: | https://doaj.org/article/5fcfe392352d4541a30312ae3ea07766Test |
| رقم الانضمام: | edsdoj.5fcfe392352d4541a30312ae3ea07766 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.32120 |