دورية أكاديمية
Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans’ egg laying behavior
| العنوان: | Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans’ egg laying behavior |
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| المؤلفون: | Amy Pribadi, Michael A Rieger, Kaila Rosales, Kirthi C Reddy, Sreekanth H Chalasani |
| المصدر: | eLife, Vol 12 (2023) |
| بيانات النشر: | eLife Sciences Publications Ltd |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | predator-prey, P. uniformis, dopamine, egg laying, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Prey respond to predators by altering their behavior to optimize their own fitness and survival. Specifically, prey are known to avoid predator-occupied territories to reduce their risk of harm or injury to themselves and their progeny. We probe the interactions between Caenorhabditis elegans and its naturally cohabiting predator Pristionchus uniformis to reveal the pathways driving changes in prey behavior. While C. elegans prefers to lay its eggs on a bacteria food lawn, the presence of a predator inside a lawn induces C. elegans to lay more eggs away from that lawn. We confirm that this change in egg laying is in response to bites from predators, rather than to predatory secretions. Moreover, predator-exposed prey continue to lay their eggs away from the dense lawn even after the predator is removed, indicating a form of learning. Next, we find that mutants in dopamine synthesis significantly reduce egg laying behavior off the lawn in both predator-free and predator-inhabited lawns, which we can rescue by transgenic complementation or supplementation with exogenous dopamine. Moreover, we find that dopamine is likely released from multiple dopaminergic neurons and requires combinations of both D1- (DOP-1) and D2-like (DOP-2 and DOP-3) dopamine receptors to alter predator-induced egg laying behavior, whereas other combinations modify baseline levels of egg laying behavior. Together, we show that dopamine signaling can alter both predator-free and predator-induced foraging strategies, suggesting a role for this pathway in defensive behaviors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/83957Test; https://doaj.org/toc/2050-084XTest; e83957; https://doaj.org/article/ed01ae923c0240f8beab993785867426Test |
| DOI: | 10.7554/eLife.83957 |
| الإتاحة: | https://doi.org/10.7554/eLife.83957Test https://doaj.org/article/ed01ae923c0240f8beab993785867426Test |
| رقم الانضمام: | edsbas.C694E22C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.83957 |