دورية أكاديمية
Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis
| العنوان: | Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis |
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| المؤلفون: | Kefei Nina Li, Prachi Jain, Catherine Hua He, Flora Chae Eun, Sangjo Kang, Tudorita Tumbar |
| المصدر: | eLife, Vol 8 (2019) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | hair follicle stem cells, vascular niche, Alk1, Runx1, skin vasculature, hair cycle, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Skin vasculature cross-talking with hair follicle stem cells (HFSCs) is poorly understood. Skin vasculature undergoes dramatic remodeling during adult mouse hair cycle. Specifically, a horizontal plexus under the secondary hair germ (HPuHG) transiently neighbors the HFSC activation zone during the quiescence phase (telogen). Increased density of HPuHG can be induced by reciprocal mutations in the epithelium (Runx1) and endothelium (Alk1) in adult mice, and is accompanied by prolonged HFSC quiescence and by delayed entry and progression into the hair growth phase (anagen). Suggestively, skin vasculature produces BMP4, a well-established HFSC quiescence-inducing factor, thus contributing to a proliferation-inhibitory environment near the HFSC. Conversely, the HFSC activator Runx1 regulates secreted proteins with previously demonstrated roles in vasculature remodeling. We suggest a working model in which coordinated remodeling and molecular cross-talking of the adult epithelial and endothelial skin compartments modulate timing of HFSC activation from quiescence for proper tissue homeostasis of adult skin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/45977Test; https://doaj.org/toc/2050-084XTest |
| DOI: | 10.7554/eLife.45977 |
| الوصول الحر: | https://doaj.org/article/b6243052e1ab4a2ba5bbf15a304b07feTest |
| رقم الانضمام: | edsdoj.b6243052e1ab4a2ba5bbf15a304b07fe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.45977 |