Brain states govern the spatio-temporal dynamics of resting-state functional connectivity
| العنوان: | Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
|---|---|
| المؤلفون: | Lara Hamzehpour, Miriam Schwalm, Felipe Aedo-Jury, Albrecht Stroh |
| المصدر: | eLife, Vol 9 (2020) eLife, 9:e53186 eLife |
| بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, QH301-705.5, Science, General Biochemistry, Genetics and Molecular Biology, Photometry, 03 medical and health sciences, functional connectivity, slow waves, optic-fiber-based calcium recordings, fMRI, slow oscillations, brain states, 0302 clinical medicine, medicine, Premovement neuronal activity, Animals, Calcium Signaling, Biology (General), Cerebral Cortex, Brain Mapping, General Immunology and Microbiology, Resting state fMRI, medicine.diagnostic_test, Chemistry, General Neuroscience, Functional connectivity, Dynamics (mechanics), General Medicine, Network dynamics, Brain Waves, Magnetic Resonance Imaging, Rats, Coupling (electronics), 030104 developmental biology, Brain state, Rat, Medicine, Female, Functional magnetic resonance imaging, Research Advance, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al., 2017). Here, using the same techniques, we investigate two distinct cortical activity states: persistent activity, in which compartmentalized network dynamics were observed; and slow wave activity, dominated by a cortex-wide BOLD component, suggesting a strong functional coupling of inter-cortical activity. During slow wave activity, we find a correlation between the occurring slow wave events and the strength of functional connectivity between different cortical areas. These findings suggest that down-up transitions of neuronal excitability can drive cortex-wide functional connectivity. This study provides further evidence that changes in functional connectivity are dependent on the brain’s current state, directly linked to the generation of slow waves. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6899fef9225988ed7f145bb25b636bTest https://elifesciences.org/articles/53186Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b6899fef9225988ed7f145bb25b636b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |