دورية أكاديمية
Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons
| العنوان: | Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons |
|---|---|
| المؤلفون: | Seelk, Stefanie, Adrian-Kalchhauser, Irene, Hargitai, Balázs, Hajduskova, Martina, Gutnik, Silvia, Tursun, Baris, Ciosk, Rafal |
| بيانات النشر: | eLife Sciences Publications |
| سنة النشر: | 2016 |
| المجموعة: | University of Basel: edoc |
| الوصف: | Cell-fate reprograming is at the heart of development, yet very little is known about the molecular mechanisms promoting or inhibiting reprograming in intact organisms. In the C. elegans germline, reprograming germ cells into somatic cells requires chromatin perturbation. Here, we describe that such reprograming is facilitated by GLP-1/Notch signaling pathway. This is surprising, since this pathway is best known for maintaining undifferentiated germline stem cells/progenitors. Through a combination of genetics, tissue-specific transcriptome analysis, and functional studies of candidate genes, we uncovered a possible explanation for this unexpected role of GLP-1/Notch. We propose that GLP-1/Notch promotes reprograming by activating specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch target facilitating reprograming. These findings have wide implications, ranging from development to diseases associated with abnormal Notch signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2050-084X |
| العلاقة: | Seelk, Stefanie and Adrian-Kalchhauser, Irene and Hargitai, Balázs and Hajduskova, Martina and Gutnik, Silvia and Tursun, Baris and Ciosk, Rafal. (2016) Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons. eLife, 5. pp. 1-22.; info:isi/000385524500001; info:pmid/27602485; urn:ISSN:2050-084X |
| DOI: | 10.7554/eLife.15477 |
| الإتاحة: | https://doi.org/10.7554/eLife.15477Test https://edoc.unibas.ch/59636Test/ |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.677ABF94 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
|---|---|
| DOI: | 10.7554/eLife.15477 |