دورية أكاديمية
Integrated β-catenin, BMP, PTEN, and notch signalling patterns the nephron
| العنوان: | Integrated β-catenin, BMP, PTEN, and notch signalling patterns the nephron |
|---|---|
| المؤلفون: | Lindström, Nils O., Lawrence, Melanie L., Burn, Sally F., Johansson, Jeanette A., Bakker, Elvira R.M., Ridgway, Rachel, Chang, C-Hong, Karolak, Michele J., Oxburgh, Leif, Headon, Denis J., Sansom, Owen J., Smits, Ron, Davies, Jamie A., Hohenstein, Peter |
| بيانات النشر: | eLife Sciences Publications |
| سنة النشر: | 2015 |
| المجموعة: | University of Glasgow: Enlighten - Publications |
| الوصف: | The different segments of the nephron and glomerulus in the kidney balance the processes of water homeostasis, solute recovery, blood filtration, and metabolite excretion. When segment function is disrupted, a range of pathological features are presented. Little is known about nephron patterning during embryogenesis. In this study, we demonstrate that the early nephron is patterned by a gradient in β-catenin activity along the axis of the nephron tubule. By modifying β-catenin activity, we force cells within nephrons to differentiate according to the imposed β-catenin activity level, thereby causing spatial shifts in nephron segments. The β-catenin signalling gradient interacts with the BMP pathway which, through PTEN/PI3K/AKT signalling, antagonises β-catenin activity and promotes segment identities associated with low β-catenin activity. β-catenin activity and PI3K signalling also integrate with Notch signalling to control segmentation: modulating β-catenin activity or PI3K rescues segment identities normally lost by inhibition of Notch. Our data therefore identifies a molecular network for nephron patterning. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://eprints.gla.ac.uk/104142/1/104142.pdfTest; Lindström, N. O. et al. (2015) Integrated β-catenin, BMP, PTEN, and notch signalling patterns the nephron. eLife , 4, e04000. (doi:10.7554/eLife.04000 ) (PMID:25647637) (PMCID:4337611) |
| الإتاحة: | https://doi.org/10.7554/eLife.04000Test http://eprints.gla.ac.uk/104142Test/ http://eprints.gla.ac.uk/104142/1/104142.pdfTest |
| حقوق: | cc_by_4 |
| رقم الانضمام: | edsbas.A21137 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |