Les complications infectieuses liées à l’utilisation des anticorps monoclonaux chez l’homme
| العنوان: | Les complications infectieuses liées à l’utilisation des anticorps monoclonaux chez l’homme |
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| المؤلفون: | Cyrille Hoarau, Emilie Rigal, Yvon Lebranchu, Philippe Gateault |
| المصدر: | médecine/sciences. 25:1135-1140 |
| بيانات النشر: | EDP Sciences, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Latent tuberculosis, biology, business.industry, medicine.drug_class, medicine.medical_treatment, Immunosuppression, General Medicine, Immunotherapy, medicine.disease, Monoclonal antibody, General Biochemistry, Genetics and Molecular Biology, Immune system, Antigen, Immunology, Monoclonal, medicine, biology.protein, Antibody, business |
| الوصف: | The large experience accumulated with the therapeutic use of monoclonal antibodies has revealed undesirable effects, among which opportunistic infections when prescribed in inflammatory or hematological diseases. This deleterious effect is a direct consequence of the immunosuppression induced by these antibodies through the blockade of several key pathways involved in both innate and adaptative immune responses, including migration of effector cells, depletion of B or T lymphocytes, inhibition of key cell-cell interactions. Four antibodies are concerned, targeting CD52, CD20, TNF-a and VLA-4, and major risks include activation of latent tuberculosis, or of normally silent viruses. Precise evaluation of these risks and understanding of their mechanisms have now led to the improvement of clinical safety, based on the detection of patients at risk, weighting of the benefit/risk ratio, and a very rigorous detection of latent infections before the onset of treatment by monoclonal antibodies know to induce immunosuppression. |
| تدمد: | 1958-5381 0767-0974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f7906ae842a3ea5081c0ea2c14fd4ed8Test https://doi.org/10.1051/medsci/200925121135Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........f7906ae842a3ea5081c0ea2c14fd4ed8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19585381 07670974 |
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