Le complexe ESCRT : du transport endosomal au développement d’organismes multicellulaires
| العنوان: | Le complexe ESCRT : du transport endosomal au développement d’organismes multicellulaires |
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| المؤلفون: | Thomas Juan, Maximilian Fürthauer |
| المصدر: | Biologie Aujourd'hui. 209:111-124 |
| بيانات النشر: | EDP Sciences, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Vesicular transport protein, ESCRT complex, Cell signaling, Endosome, Endosomal transport, Cellular homeostasis, Biology, General Biochemistry, Genetics and Molecular Biology, ESCRT, Biogenesis, Cell biology |
| الوصف: | Since its discovery more than 50 years ago, the endo-lysosomal system has emerged as a central integrator of different cellular activities. This vesicular trafficking apparatus governs processes as diverse as the transduction of stimuli by growth factor receptors, the recycling and secretion of signaling molecules and the regulation of cellular homeostasis through autophagy. Accordingly, dysfunctions of the vesicular transport machinery have been linked to a growing number of pathologies. In this review we take the "Endosomal Sorting Complex Required for Transport" (ESCRT) as an example to illustrate the multiple functions of an evolutionarily conserved endosomal transport machinery. We describe the major concepts that have emerged from the study of this machinery at the level of the development and the physiology of multi-cellular organisms. In particular, we highlight the essential contributions of ESCRT proteins on the regulation of three biological processes: the endocytic regulation of cell signaling, autophagy and its role in neuronal morphogenesis and finally the biogenesis and function of extracellular vesicles. |
| تدمد: | 2105-0686 2105-0678 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f617b212dc4a40d7a8b41ab33bcd3be6Test https://doi.org/10.1051/jbio/2015009Test |
| رقم الانضمام: | edsair.doi...........f617b212dc4a40d7a8b41ab33bcd3be6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21050686 21050678 |
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