دورية أكاديمية
Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals
| العنوان: | Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals |
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| المؤلفون: | R. M. Ruggeri, A. Vitale, P. Cardelli, M. Galletti, E. Vitarelli, G. Barresi, S. Benvenga, F. Trimarchi, M. Trovato, SCIACCHITANO, Salvatore |
| المساهمون: | R. M., Ruggeri, Sciacchitano, Salvatore, A., Vitale, P., Cardelli, M., Galletti, E., Vitarelli, G., Barresi, S., Benvenga, F., Trimarchi, M., Trovato |
| بيانات النشر: | EDITRICE KURTIS S R L |
| سنة النشر: | 2009 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | growth factor, hashimoto's thyroiditi, hepatocyte growth factor, interleukin 6, thyroid nodules |
| الوصف: | BACKGROUND: Some growth factors and cytokines are known to cooperate with TSH in thyroid nodular growth, but few data are available on their circulating levels in Hashimoto's thyroiditis (HT). AIM: To evaluate in HT patients whether thyroid nodules are associated with variations in serum levels of hepatocyte growth factor (HGF) and interleukin-6 (IL-6). SUBJECTS AND METHODS: Serum levels of HGF and IL-6 were measured by enzyme-linked immunosorbent assay in 176 euthyroid subjects, subdivided into 4 groups: A) HT patients with nodular goiter (no.=42); B) non-goitrous HT patients (no.=36); C) non-HT patients with nodular goiter (no.=48), and D) healthy subjects without thyroid disease (no.=50). RESULTS: The highest concentrations of serumHGF were found in patients with nodular goiter, irrespective of the presence of associated HT (groups A and C). Nevertheless, in group A serum HGF levels were significantly higher than in group C (860.8+/-333.6 pg/ml vs 691.5+/-156 pg/ml, p<0.01). Moreover, though serum HGF levels in group B (578.3+/-217 pg/ml) were lower than in group A, they were significantly higher than in healthy controls (group D, 512.7+/-170.4 pg/ml, p<0.001). Serum IL-6 levels were similar in the two HT groups (A and B), and increased with respect to groups C and D. CONCLUSIONS: Serum HGF is increased in HT, especially associated to thyroid nodules, as compared with healthy non-goitrous individuals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19468262; info:eu-repo/semantics/altIdentifier/wos/WOS:000270471500015; volume:32; issue:5; firstpage:465; lastpage:469; numberofpages:5; journal:JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION; http://hdl.handle.net/11573/229632Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-70350302624; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000270471500015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-70350302624&partnerID=65&md5=881654f03ef375d2d1679069dc714862Test |
| DOI: | 10.3275/6104 |
| الإتاحة: | https://doi.org/10.3275/6104Test http://hdl.handle.net/11573/229632Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000270471500015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-70350302624&partnerID=65&md5=881654f03ef375d2d1679069dc714862Test |
| رقم الانضمام: | edsbas.14A4D7B3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3275/6104 |
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