Objective To provide theoretical basis for the clinical application of pyroptosis, we analyzed the related literature of focal death to understand the research prospects and hot spots in recent ten years. Methods We searched the Web of Science for all the literature related to pyroptosis from 2009 to 2019. CiteSpace software was used for bibliometric analysis. Using the generated network map to evaluate and infer the characteristics of pyroptosis in several indicators, such as author, country, institution, key words and references. Results 1389 literatures related to pyroptosis from 2009 to 2019 were published. The number of articles published in each year is increasing rapidly with the year. St Jude Childrens Res Hosp became the largest publishing agency. There is active cooperation among authors in various fields. The United States is a major contributor to the articles in the field of pyroptosis. Biology, molecular science and immunology have become the main research subjects. The main hot topics include cell death, apoptosis and activation. Conclusions In recent years, the research form of pyroptosis has gradually increased, and the research scope has become larger and larger, research depth is also deeper and deeper. We should consider how to further explore its value in future research, so that it can better serve medicine and human beings. DOI: 10.11855/j.issn.0577-7402.2020.08.07
