دورية أكاديمية
In vitro selection of resistance to clarithromycin in Streptococcus pneumoniae clinical isolates
| العنوان: | In vitro selection of resistance to clarithromycin in Streptococcus pneumoniae clinical isolates |
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| المؤلفون: | L. Drago, LEGNANI, DELFINO, L. Nicola, E. De Vecchi, S. Ripa, M. Prenna |
| المساهمون: | L. Drago, D. Legnani, L. Nicola, E. De Vecchi, S. Ripa, M. Prenna |
| بيانات النشر: | E.I.F.T |
| سنة النشر: | 2005 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Streptococcus pneumoniae, antibiotic resistance, antibiotic sensitivity, article, bacterial strain, bacterium isolate, controlled study, drug exposure, in vitro selection, lung, minimum inhibitory concentration, mutation rate, nonhuman, spontaneous mutation, agar, amoxicillin plus clavulanic acid, azithromycin, clarithromycin, levofloxacin, moxifloxacin, Settore MED/10 - Malattie dell'Apparato Respiratorio, Settore MED/07 - Microbiologia e Microbiologia Clinica |
| الوصف: | In this study the effects of exposure to serum, lung and breakpoint concentrations on Streptococcus pneumoniae susceptibility to clarithromycin, azithromycin, amoxicillin/clavulanate, levofloxacin and moxifloxacin were evaluated. Development of resistance was determined by multi-step and single-step methodologies. In the first experimental set, minimum inhibitory concentrations (MICs) were determined after 10 passages on antibiotic-gradient plates and 10 passages on antibiotic-free plates. Acquisition of resistance was defined as an increase of (greater-than or equal to)4-fold from the starting MIC. In single-step studies, the rate of spontaneous mutations was calculated after a passage on antibiotic-containing agar plates. Azithromycin and levofloxacin gave the highest number of strains with MIC increased of at least 4 times the starting value, followed by moxifloxacin and by clarithromycin which only at the lowest concentration tested selected for resistance in 5 strains. Amoxicillin/ clavulanate never displayed (greater-than or equal to)4-fold MIC increase. Frequencies of mutation were lower for clarithromycin and moxifloxacin than for the comparators. At lung concentrations clarithromycin had limited potential to select for resistance. (copyright) E.S.I.F.T. srl - Firenze. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000229303900005; volume:17; issue:2; firstpage:161; lastpage:168; journal:JOURNAL OF CHEMOTHERAPY; http://hdl.handle.net/2434/9385Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-19544387748 |
| DOI: | 10.1179/joc.2005.17.2.161 |
| الإتاحة: | https://doi.org/10.1179/joc.2005.17.2.161Test http://hdl.handle.net/2434/9385Test |
| رقم الانضمام: | edsbas.F79878D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1179/joc.2005.17.2.161 |
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