Predictive value of 1q21 gain in multiple myeloma is strongly dependent on concurrent cytogenetic abnormalities and first-line treatment
| العنوان: | Predictive value of 1q21 gain in multiple myeloma is strongly dependent on concurrent cytogenetic abnormalities and first-line treatment |
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| المؤلفون: | Minguela, Alfredo, Vasco-Mogorron, Maria A., Campillo, Jose A., Cabanas, Valentin, Remigia, Maria J., Berenguer, Mercedes, Garcia-Garay, Maria C., Blanquer, Miguel, Cava, Catalina, Galian, Jose Antonio, Gimeno, Lourdes, Soto-Ramirez, Maria F., Martinez-Hernandez, Maria D., de la Rubia, Javier, Teruel, I, Ana, Muro, Manuel, Periago, Adela |
| المصدر: | Am J Cancer Res American Journal of Cancer Research r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| بيانات النشر: | e-Century Publishing Corporation, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | multiple myeloma, t(4, autologous stem cell transplantation, High-risk cytogenetic abnormalities, 1q21 gain, High-risk cytogenetic abnormalities, autologous stem cell transplantation, del(17p), immunomodulatory and proteasome inhibitor treatments, multiple myeloma, plasma cell neoplasm, t(4, immunomodulatory and proteasome inhibitor treatments, del(17p), 14), Original Article, plasma cell neoplasm, 1q21 gain |
| الوصف: | Improved therapies in multiple myeloma (MM) have forced a constant risk stratification update, first Durie-Salmon, then international scoring systems (ISS), next revised-ISS (RISS) including high-risk cytogenetic abnormalities (HRCAs) such as del(17p) and t(4;14), and now R2-ISS including 1q21 gain has been proposed. Predictive value of 1q21 gain by itself or in concurrence with other cytogenetic abnormalities is evaluated in 737 real-world plasma cell neoplasm (PCN) patients under current therapies. Ten-year progression-free survival (10y-PFS) rates for patients with 2, 3 and 3 copies of 1q21 were 72.2%, 42.5% and 43.4% (P |
| اللغة: | English |
| تدمد: | 2156-6976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d3fd0c6650533becce8c808b464ac057Test https://europepmc.org/articles/PMC8493371Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....d3fd0c6650533becce8c808b464ac057 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21566976 |
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