Changes in lipid peroxidation system during standard therapy for exogenous constitutional obesity in adolescents of different sex
| العنوان: | Changes in lipid peroxidation system during standard therapy for exogenous constitutional obesity in adolescents of different sex |
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| المؤلفون: | Marina A. Darenskaya, Sergey Kolesnikov |
| المصدر: | Voprosy detskoj dietologii. 20:5-11 |
| بيانات النشر: | Dynasty Publishing House, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Nutrition and Dietetics, Pediatrics, Perinatology and Child Health, Food Science |
| الوصف: | Objective. To reveal changes in lipid peroxidation parameters and antioxidant protection components against the background of standard non-pharmacological therapy for exogenous constitutional obesity in adolescents of different sex. Patients and methods. Forty-six adolescents aged 12–17 years with obesity were examined before and after non-pharmacological therapy. The control group included 36 healthy adolescents. We analyzed the composition of lipid peroxidation products – conjugated dienes (CD), ketodienes and conjugated trienes (KD and CT), TBA-active products and activity of antioxidant protection factors: total antioxidant activity (AOA), levels of α-tocopherol, retinol, reduced and oxidized glutathione (GSH, GSSG), their ratio (GSH/GSSG ratio), superoxide dismutase (SOD) activity. Spectrophotometric and fluorometric methods were used. Results. Male adolescents with obesity had lower values of primary lipid peroxidation products compared to the control group – CD (1.35-fold, p = 0,001) and antioxidant protection factors: total AOA (1.16-fold, p = 0,036) and SOD activity (1.49-fold, p < 0.0001), whereas secondary products – KD and CT were elevated (1.42-fold, p = 0,046). Standard therapy in male adolescents did not lead to normalization of the studied parameters. Significantly lower were the values of total AOA (1.4-fold, p = 0.0001), SOD activity (1.42-fold, p < 0.0001) and α-tocopherol (1.33-fold, p = 0.012) in female adolescents with exogenous constitutional obesity compared to the control group. After standard therapy, there was an increase in GSSG levels (1.14-fold, p = 0.029). Conclusion. The presence of negative changes in the pro- and antioxidant status in adolescents with obesity, which was not normalized after a course of standard therapy, was shown. Additional pharmacological correction by prescription of antioxidant drugs becomes relevant. Key words: antioxidant protection, standard therapy, oxidative stress, adolescents, exogenous constitutional obesity |
| تدمد: | 2414-9519 1727-5784 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9b915a3b1336004123fee2ffe266b429Test https://doi.org/10.20953/1727-5784-2022-1-5-11Test |
| رقم الانضمام: | edsair.doi...........9b915a3b1336004123fee2ffe266b429 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24149519 17275784 |
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