دورية أكاديمية
Treatment of multiple sclerosis relapses with high-dose methylprednisolone reduces the evolution of contrast-enhancing lesions into persistent black holes
| العنوان: | Treatment of multiple sclerosis relapses with high-dose methylprednisolone reduces the evolution of contrast-enhancing lesions into persistent black holes |
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| المؤلفون: | Calabresi P. |
| المساهمون: | Di Gregorio, M., Gaetani, L., Eusebi, P., Floridi, P., Picchioni, A., Rosi, G., Mancini, A., Floridi, C., Baschieri, F., Gentili, L., Sarchielli, P., Calabresi, Paolo, Di Filippo, M. |
| بيانات النشر: | Dr. Dietrich Steinkopff Verlag GmbH and Co. KG |
| سنة النشر: | 2018 |
| المجموعة: | Università Cattolica del Sacro Cuore: PubliCatt |
| مصطلحات موضوعية: | Black holes, Methylprednisolone, Multiple sclerosis, Steroid, Adolescent, Adult, Aged, Brain, Disease Progression, Female, Follow-Up Studies, Glucocorticoids, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Relapsing-Remitting, Multivariate Analysis, Neuroprotective Agents, Retrospective Studies, Treatment Outcome, Young Adult, Settore MED/26 - NEUROLOGIA |
| الوصف: | Introduction: The MRI evidence of persistent black holes (pBHs) on T1-weighted images reflects brain tissue loss in multiple sclerosis (MS). The evolution of contrast-enhancing lesions (CELs) into pBHs probably depends on the degree and persistence of focal brain inflammation. The aim of our retrospective study was to evaluate the effect of a single cycle of intravenous methylprednisolone (IVMP), as for MS relapse treatment, on the risk of CELs’ evolution into pBHs. Patients and methods: We selected 57 patients with CELs on the baseline MRI scan. We evaluated the evolution of CELs into pBHs on a follow-up MRI scan performed after ≥ 6 months in patients exposed and not exposed to IVMP for the treatment of relapse after the baseline MRI. Results: In our cohort, 182 CELs were identified in the baseline MRI and 57 of them (31.3%) evolved into pBHs. In the multivariate analysis, the exposure of CELs to IVMP resulted to be a significant independent protective factor against pBHs’ formation (OR 0.28, 95% CI 0.11–0.766, p = 0.005), while ring enhancement pattern and the fact of being symptomatic were significant risk factors for CELs’ conversion into pBHs (OR 6.42, 95% CI 2.55–17.27, p OpenSPiltSPi 0.001 and OR 13.19, 95% CI 1.56–288.87, p = 0.037). Conclusions: The exposure of CELs to a cycle of IVMP as for relapse treatment is associated with a lower risk of CELs’ evolution into pBHs. Future studies are required to confirm the potential independent protective effect of IVMP on CELs’ evolution into pBHs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29327284; info:eu-repo/semantics/altIdentifier/wos/WOS:000426654600008; volume:265; issue:3; firstpage:522; lastpage:529; numberofpages:8; issueyear:2018; journal:JOURNAL OF NEUROLOGY; http://hdl.handle.net/10807/171436Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85040362536 |
| DOI: | 10.1007/s00415-017-8726-2 |
| الإتاحة: | https://doi.org/10.1007/s00415-017-8726-2Test http://hdl.handle.net/10807/171436Test |
| رقم الانضمام: | edsbas.72D5FC9B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00415-017-8726-2 |
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