دورية أكاديمية
The Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders
| العنوان: | The Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders |
|---|---|
| المؤلفون: | Gao,Shangzhi, Quick,Corbin, Guasch-Ferre,Marta, Zhuo,Zhu, Hutchinson,John M, Su,Li, Hu,Frank, Lin,Xihong, Christiani,David |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2021 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | Journal of Inflammation Research |
| الوصف: | Shangzhi Gao,1 Corbin Quick,2 Marta Guasch-Ferre,3 Zhu Zhuo,2 John M Hutchinson,2 Li Su,1 Frank Hu,3 Xihong Lin,2 David Christiani1,4 1Environmental Health, Harvard University T H Chan School of Public Health, Boston, MA, USA; 2Biostatistics, Harvard University T H Chan School of Public Health, Boston, MA, USA; 3Nutrition, Harvard University T H Chan School of Public Health, Boston, MA, USA; 4Pulmonary and Critical Care Division, Department of Medicine, MA General Hospital, Boston, Massachusetts, USACorrespondence: David ChristianiEnvironmental Health, Harvard University T H Chan School of Public Health, Boston, MA, 02115, USAEmail dchris@hsph.harvard.eduIntroduction: Human metabolism and inflammation are closely related modulators of homeostasis and immunity. Metabolic profiling is a useful tool to understand the association between metabolism and inflammation at a systemic level.Objective: To investigate the longitudinal associations between the concentration of plasma metabolites and biomarkers related to inflammation and oxidative stress.Methods: We conducted a repeated cross-sectional analysis consisting of 8 short-term panels that included 88 healthy adult male welders in Massachusetts, USA. In each panel, we collected 1– 6 repeated measurements of blood and urine. We used a human vascular injury panel assay and custom cytokine/chemokine assay to quantify inflammatory biomarker plasma levels, liquid chromatography-mass spectrometry to quantify the concentrations of 665 plasma metabolites, and a competitive enzyme-linked immunoassay to quantify urinary 8-OHdG and 8-isoprostane levels. We used linear mixed effects models to estimate the longitudinal association between each inflammatory and oxidative stress biomarker and each metabolite.Results: At a 5% FDR threshold, we detected ≥ 1metabolite association for 8 unique inflammatory and oxidative stress biomarkers: urinary 8-isoprostane, plasma C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule 1, circulating vascular cell ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/the-association-between-inflammatory-and-oxidative-stress-biomarkers-a-peer-reviewed-fulltext-article-JIRTest |
| الإتاحة: | https://doi.org/10.2147/JIR.S316262Test https://www.dovepress.com/the-association-between-inflammatory-and-oxidative-stress-biomarkers-a-peer-reviewed-fulltext-article-JIRTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9F51BE60 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |