دورية أكاديمية
Inadequacy of Vitamin D Nutritional Status in Individuals with Metabolically Unhealthy Obesity Phenotype: The Relevance of Insulin Resistance
| العنوان: | Inadequacy of Vitamin D Nutritional Status in Individuals with Metabolically Unhealthy Obesity Phenotype: The Relevance of Insulin Resistance |
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| المؤلفون: | Cordeiro,A, Campos,B, Pereira,SE, Saboya,CJ, Ramalho,A |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2020 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| الوصف: | A Cordeiro,1,2 B Campos,3 SE Pereira,1 CJ Saboya,3 A Ramalho1 1Department of Social Applied Nutrition, Micronutrients Research Center (NPqM), Institute of Nutrition, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; 2Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal; 3Multidisciplinary Center of Bariatric and Metabolic Surgery Carlos Saboya, Rio de Janeiro, BrazilCorrespondence: A Cordeiro Al. Prof. Hernâni Monteiro, Porto 4200 - 319, PortugalTel +351-966669689Fax +351 220 426 937Email cordeiroadryana@gmail.comPurpose: The aim was to evaluate 25(OH)D serum concentrations in metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO) and its relation with biochemical and clinical parameters in both groups according to homeostatic model assessment-insulin resistance (HOMA-IR) definition of the obesity phenotypes.Patients and Methods: Descriptive cross-sectional study was conducted with individuals of both genders. Anthropometric data [waist circumference, body mass index (BMI)] and metabolic parameters: blood glucose, glycated hemoglobin, insulin, lipid profile, calcium, phosphorus, parathyroid hormone (PTH) and high-sensitivity c-reactive protein (hs-CRP) and (25(OH)D) were obtained. The cutoff points for vitamin D deficiency and insufficiency were ≤ 20 and 21– 29 ng/mL, respectively. Individuals were classified as MUHO according to HOMA-IR≥ 2.5.Results: This study comprised 232 individuals with obesity (BMI≥ 35 kg/m2; 42.6± 4.7 kg/m2). The MUHO phenotype was observed in 76.7% of the population. The mean values of glucose (P< 0.001), insulin (P< 0.001), HOMA-IR (P< 0.001), and triglycerides (P=0.049) were significantly higher in the MUHO than in the MHO phenotype group. The mean value of 25(OH)D showed a significant difference between the MHO and MUHO phenotype groups (P=0.011). Additionally, and in line, lower mean 25(OH)D values were found in the MUHO vs the MHO phenotype group in the deficiency ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/inadequacy-of-vitamin-d-nutritional-status-in-individuals-with-metabol-peer-reviewed-fulltext-article-DMSOTest |
| الإتاحة: | https://doi.org/10.2147/DMSO.S256132Test https://www.dovepress.com/inadequacy-of-vitamin-d-nutritional-status-in-individuals-with-metabol-peer-reviewed-fulltext-article-DMSOTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CCB66674 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |